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用于促进感染性伤口愈合的光热水凝胶。

Photothermal Hydrogels for Promoting Infected Wound Healing.

机构信息

Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, 430074, China.

出版信息

Macromol Biosci. 2023 Feb;23(2):e2200378. doi: 10.1002/mabi.202200378. Epub 2022 Nov 16.

Abstract

Photothermal therapies (PTT), with spatiotemporally controllable antibacterial capabilities without inducing resistance, have shown encouraging prospects in the field of infected wound treatments. As an important platform for PTT, photothermal hydrogels exhibit attractive advantages in the field of infected wound treatment due to their excellent biochemical properties and have been intensively explored in recent years. This review summarizes the progress of the photothermal hydrogels for promoting infected wound healing. Three major elements of photothermal hydrogels, i.e., photothermal materials, hydrogel matrix, and construction methods, are introduced. Furthermore, different strategies of photothermal hydrogels in the treatment of infected wounds are summarized. Finally, the challenges and prospects in the clinical treatment of photothermal hydrogels are discussed.

摘要

光热疗法(PTT)具有时空可控的抗菌能力,且不会诱导耐药性,在感染性伤口治疗领域显示出了令人鼓舞的前景。作为 PTT 的一个重要平台,光热水凝胶由于其优异的生化特性,在感染性伤口治疗领域具有吸引力,近年来得到了深入探索。本综述总结了用于促进感染性伤口愈合的光热水凝胶的研究进展。介绍了光热水凝胶的三个主要组成部分,即光热材料、水凝胶基质和构建方法。此外,还总结了光热水凝胶在治疗感染性伤口方面的不同策略。最后,讨论了光热水凝胶在临床治疗方面面临的挑战和前景。

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