Kuznetsov K O, Khaidarova R R, Khabibullina R H, Stytsenko E S, Filosofova V I, Nuriakhmetova I R, Hisameeva E M, Vazhorov G S, Khaibullin F R, Ivanova E A, Gorbatova K V
N.I. Pirogov Russian national research medical university.
Bashkir state medical university.
Probl Endokrinol (Mosk). 2022 Jun 24;68(5):97-107. doi: 10.14341/probl13136.
Alzheimer's disease (AD) is a neurodegenerative disease that causes dementia in half of the cases. Asthma is usually found in people over 65 years of age. The etiopathogenesis of the disease is multifactorial and includes genetic factors, nutritional disorders, mitochondrial dysfunction, oxidative stress, and aging. Sex hormones have an important influence on the development of AD, as evidenced by a higher incidence in women than in men. Considering the significant influence of T on the maintenance of normal brain function, the present study is aimed at evaluating the impact of androgen deprivation therapy (ADT), as well as testosterone therapy, on the risk of AD development and progression. Although there is some clinical inconsistency between studies, androgens have a significant effect on brain function and are beneficial for AD patients. Low levels of circulating androgens should be considered as a significant risk factor for the development of AD and memory loss. With a reduced level of T in the plasma of men, its administration improves cognitive performance and memory, treatment should be started at an early stage of the disease. In men and women with AD, androgens improve mental state and slow the progression of the disease, providing a protective effect. In the future, it is necessary to conduct studies on a large population, taking into account personality factors and a more specific approach to assessing cognitive functions and the causal relationship of T administration in AD.
阿尔茨海默病（AD）是一种神经退行性疾病，半数病例会导致痴呆。哮喘通常见于65岁以上人群。该疾病的病因发病机制是多因素的，包括遗传因素、营养紊乱、线粒体功能障碍、氧化应激和衰老。性激素对AD的发展有重要影响，女性发病率高于男性就证明了这一点。考虑到睾酮对维持正常脑功能的重大影响，本研究旨在评估去势雄激素治疗（ADT）以及睾酮治疗对AD发生和进展风险的影响。尽管研究之间存在一些临床不一致性，但雄激素对脑功能有显著影响，对AD患者有益。循环雄激素水平低应被视为AD发生和记忆丧失的重要危险因素。男性血浆中睾酮水平降低时，补充睾酮可改善认知表现和记忆，应在疾病早期开始治疗。在患有AD的男性和女性中，雄激素可改善精神状态并减缓疾病进展，起到保护作用。未来，有必要针对大量人群开展研究，同时考虑人格因素以及采用更具体的方法来评估认知功能和AD中睾酮补充的因果关系。
