Dudek Bartłomiej, Rybka Jacek, Bugla-Płoskońska Gabriela, Korzeniowska-Kowal Agnieszka, Futoma-Kołoch Bożena, Pawlak Aleksandra, Gamian Andrzej
Department of Microbiology, University of Wrocław, Wrocław, Poland.
Department of Immunology of Infectious Diseases, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Front Microbiol. 2022 Oct 20;13:1028796. doi: 10.3389/fmicb.2022.1028796. eCollection 2022.
Lipopolysaccharide (endotoxin, LPS) is an important Gram-negative bacteria antigen. LPS of some bacteria contains sialic acid (Neu5Ac) as a component of O-antigen (O-Ag), in this review we present an overview of bacteria in which the presence of Neu5Ac has been confirmed in their outer envelope and the possible ways that bacteria can acquire Neu5Ac. We explain the role of Neu5Ac in bacterial pathogenesis, and also involvement of Neu5Ac in bacterial evading the host innate immunity response and molecular mimicry phenomenon. We also highlight the role of sialic acid in the mechanism of bacterial resistance to action of serum complement. Despite a number of studies on involvement of Neu5Ac in bacterial pathogenesis many aspects of this phenomenon are still not understood.
脂多糖（内毒素，LPS）是一种重要的革兰氏阴性菌抗原。某些细菌的LPS含有唾液酸（Neu5Ac）作为O抗原（O-Ag）的一个组成部分，在本综述中，我们概述了已在其外膜中证实存在Neu5Ac的细菌，以及细菌获取Neu5Ac的可能途径。我们解释了Neu5Ac在细菌致病机制中的作用，以及Neu5Ac在细菌逃避宿主固有免疫反应和分子模拟现象中的作用。我们还强调了唾液酸在细菌抵抗血清补体作用机制中的作用。尽管对Neu5Ac参与细菌致病机制进行了大量研究，但这一现象的许多方面仍不清楚。
