教育和鼓励性干预对人体测量特征和脂联素-1水平的影响：TABASSOM研究

The effect of educational and encouraging interventions on anthropometric characteristics and perilipin-1 levels: TABASSOM Study.

作者信息

Maghroun Maryam, Mohammadifard Noushin, Sajjadi Firoozeh, Jafaridinani Narges, Karimi Simin, Rabiei Katayoun, Massoudi Soraya, Sarrafzadegan Nizal

机构信息

Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Assistant Professor, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

ARYA Atheroscler. 2021 Mar;17(2):1-7. doi: 10.22122/arya.v17i0.1698.

DOI:10.22122/arya.v17i0.1698

PMID:36338526

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9635725/

Abstract

BACKGROUND

Perilipin protein located in lipid droplets is involved in formation and storage of lipid in adipocytes; thus, it is considered as one of the obesity biomarkers. This study was performed to examine the effect of educational and encouragement interventions and lifestyle modifications on anthropometric characteristics and perilipin-1 level.

METHODS

This quasi-experimental study was conducted on subsample of TABASSOM Study. Participants were 42 overweight and obese children and adolescents aged 6-18 years old and 80 overweight and obese adults aged 19-65 years old. Anthropometric characteristics including weight, height, waist circumference (WC), body fat percentage (BFP), and perilipin-1 level were measured at the first and the end of study (after one year).

RESULTS

After intervention, the mean of perilipin-1 decreased significantly in total children and adolescents (before vs. after: 26.79 ± 13.17 vs. 22.57 ± 8.03; P = 0.006) and girls (27.75 ± 10.51 vs. 22.00 ± 8.15; P = 0.001), but decreasing was not significant in boys. In adults, perilipin-1 levels were significantly reduced in total subjects (before vs. after: 16.19 ± 13.42 vs. 15.34 ± 11.25; P = 0.029) and men (18.02 ± 15.78 vs. 15.44 ± 10.61; P = 0.003). There was no significant difference in mean of body mass index (BMI), WC, and BFP in both groups after 12 months.

CONCLUSION

Educational and encouraging interventions and lifestyle modifications could lead to decreasing perilipin-1 level in adults, children, and adolescents.

摘要

背景

位于脂滴中的围脂滴蛋白参与脂肪细胞中脂质的形成和储存；因此，它被认为是肥胖生物标志物之一。本研究旨在探讨教育与鼓励干预及生活方式改变对人体测量学特征和围脂滴蛋白-1水平的影响。

方法

本准实验研究是在TABASSOM研究的子样本上进行的。参与者为42名6至18岁的超重和肥胖儿童及青少年，以及80名19至65岁的超重和肥胖成年人。在研究开始时和结束时（一年后）测量人体测量学特征，包括体重、身高、腰围（WC）、体脂百分比（BFP）和围脂滴蛋白-1水平。

结果

干预后，儿童和青少年总体（干预前vs.干预后：26.79±13.17 vs. 22.57±8.03；P = 0.006）及女孩（27.75±10.51 vs. 22.00±8.15；P = 0.001）的围脂滴蛋白-1平均值显著降低，但男孩的降低不显著。在成年人中，总体受试者（干预前vs.干预后：16.19±13.42 vs. 15.34±11.25；P = 0.029）及男性（18.02±15.78 vs. 15.44±10.61；P = 0.003）的围脂滴蛋白-1水平显著降低。12个月后，两组的体重指数（BMI）、腰围和体脂百分比平均值均无显著差异。