Paqué Pune Nina, Hjerppe Jenni, Zuercher Anina N, Jung Ronald E, Joda Tim
Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Department of Reconstructive Dentistry, University Center of Dental Medicine, University of Basel, Basel, Switzerland.
Front Oral Health. 2022 Sep 22;3:1003679. doi: 10.3389/froh.2022.1003679. eCollection 2022.
Personalized Oral Healthcare has recently become the new trend word in medicine and dentistry. In this context, saliva diagnostics using various biomarkers seem to be the gateway to personalized dental diagnostics and therapy. But the terminology is not (yet) uniformly defined, furthermore it is unclear to what extent which salivary markers play a relevant role in the therapeutic decision making. In this Scoping Review, an electronic search was conducted in PubMed and Web of Science databases using medical subject headings (MESH terms) "saliva", "biomarker", "personality/persons", and "dentistry". Only human studies were included, in which repeated salivary measurements were performed to analyze monitoring effects with at least ten patients per group. PRISMA-ScR and Tricco guidelines were followed: (i) to examine what salivary biomarkers have been explored in terms of personalized oral healthcare and precision dentistry, (ii) to investigate the clinical relevance for oral health and its correlation to systemic health, and (iii) to summarize an outlook for future developments based on these results. Out of 899 studies, a total of 57 were included for data extraction in this Scoping Review, mainly focusing on periodontal therapy and patient monitoring. Salivary biomarkers have shown the potential to change the field of dentistry in all dental disciplines as a key for personalized workflows. The increasing interest in dental research is obvious, demonstrated by the growing number of publications in recent years. At this time, however, the predominant discipline is periodontology, which allows biomarker-based monitoring of the disease prevention and progression. The studies included showed heterogeneous methods using manifolds biomarkers. Therefore, no uniformly accepted concept can be presented today. Further clinical research with well-defined outcomes including standardized procedures is necessary.
个性化口腔保健最近已成为医学和牙科领域的新流行词汇。在这种背景下，利用各种生物标志物进行唾液诊断似乎是通向个性化牙科诊断和治疗的大门。但该术语（目前）尚未统一界定，此外，尚不清楚哪些唾液标志物在多大程度上对治疗决策具有相关作用。在本范围综述中，我们在PubMed和Web of Science数据库中使用医学主题词（MeSH词）“唾液”“生物标志物”“个性/人”和“牙科”进行了电子检索。仅纳入了人体研究，其中进行了重复唾液测量以分析监测效果，每组至少有10名患者。遵循PRISMA-ScR和Tricco指南：（i）研究在个性化口腔保健和精准牙科方面探索了哪些唾液生物标志物；（ii）调查其对口腔健康的临床相关性及其与全身健康的相关性；（iii）基于这些结果总结未来发展的展望。在899项研究中，本范围综述共纳入57项进行数据提取，主要集中在牙周治疗和患者监测方面。唾液生物标志物已显示出作为个性化工作流程关键在所有牙科领域改变牙科的潜力。近年来出版物数量不断增加，表明对牙科研究的兴趣日益明显。然而，目前主要的学科是牙周病学，它允许基于生物标志物对疾病预防和进展进行监测。纳入的研究显示使用多种生物标志物的方法各异。因此，目前无法提出一个统一接受的概念。需要进一步开展具有明确结果（包括标准化程序）的临床研究。
