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1-{3-[(7-氟-9-嘧啶并[4,5-]吲哚-4-基)(甲基)氨基]-哌啶-1-基}丙-1-酮

1-{3-[(7-Fluoro-9-pyrimido[4,5-]indol-4-yl)(meth-yl)amino]-piperidin-1-yl}propan-1-one.

作者信息

Andreev Stanislav, Schollmeyer Dieter, Koch Pierre

机构信息

Institute of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.

Department of Organic Chemistry, Johannes Gutenberg Universität Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.

出版信息

IUCrdata. 2021 Feb 23;6(Pt 2):x210159. doi: 10.1107/S2414314621001590. eCollection 2021 Feb.

DOI:10.1107/S2414314621001590
PMID:36338864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9462319/
Abstract

The title compound, CHFNO, has been synthesized as an inhibitor of glycogen synthase kinase-3β. Two mol-ecules inter-act two N-H⋯N hydrogen bonds, forming centrosymmetric dimers.

摘要

标题化合物CHFNO已被合成为糖原合酶激酶-3β的抑制剂。两个分子通过两个N-H⋯N氢键相互作用，形成中心对称二聚体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea8d/9462319/bb14fc16712b/x-06-x210159-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea8d/9462319/d7d79c02af28/x-06-x210159-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea8d/9462319/bb14fc16712b/x-06-x210159-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea8d/9462319/d7d79c02af28/x-06-x210159-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea8d/9462319/bb14fc16712b/x-06-x210159-fig2.jpg

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本文引用的文献

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