Gupta Vandana, Kaur Harpreet, Yadav Vikender Singh, Kala Sunny, Mishra Deepika
Centre for Dental Education and Research, Division of Periodontics, All India Institute of Medical Sciences, New Delhi, India.
Department of Oral Pathology and Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
J Indian Soc Periodontol. 2022 Sep-Oct;26(5):434-439. doi: 10.4103/jisp.jisp_67_21. Epub 2022 Sep 1.
This study aims to describe the demographics and clinicopathological characteristics of the cases of plasma cell gingivitis (PCG) reported in our institute, supported by a review of pertinent literature. Further, we investigated the role of the cluster of differentiation CD138, Ki67, CD56, and CD117 immunoexpression in the differential diagnosis of PCG from plasma cell dyscrasias.
All histopathologically confirmed cases of PCG, whose relevant details could be obtained, were included in this study. They were subjected to panel of immunohistochemical markers to exclude plasma cell malignancies. Further, published English literature for PCG since 1970-2020 was reviewed.
Nine histopathologically confirmed cases of PCG, were retrieved from the archives of our department. The cases comprised 3 males and 6 females with their ages ranging between 14 and 82 years. The plasma cells exhibited equivocal reactivity for kappa and lambda; and immunonegativity for CD56, CD117 with low Ki67 proliferation index. Published literature in English showed 43 cases of PCG were predominantly female; the diffuse involvement of maxilla and mandible was a common finding.
In addition to kappa lambda reactivity, an immunoprofile of CD138, Ki67, CD56, and CD117 may be used as a diagnostic adjunct to exclude malignant plasma cell lesions in confusing cases.
本研究旨在描述我院报告的浆细胞性龈炎（PCG）病例的人口统计学和临床病理特征，并辅以相关文献综述。此外，我们研究了分化簇CD138、Ki67、CD56和CD117免疫表达在PCG与浆细胞发育异常的鉴别诊断中的作用。
本研究纳入所有经组织病理学确诊且能获取相关细节的PCG病例。对其进行一组免疫组化标记物检测以排除浆细胞恶性肿瘤。此外，回顾了1970年至2020年以来发表的关于PCG的英文文献。
从我院病理档案中检索到9例经组织病理学确诊的PCG病例。这些病例包括3名男性和6名女性，年龄在14岁至82岁之间。浆细胞对κ和λ表现出不明确的反应性；对CD56、CD117呈免疫阴性，Ki67增殖指数较低。英文发表文献显示43例PCG病例以女性为主；上颌骨和下颌骨的弥漫性受累是常见表现。
除κλ反应性外，CD138、Ki67、CD56和CD117的免疫表型可作为诊断辅助手段，用于在疑难病例中排除恶性浆细胞病变。
