J Clin Pediatr Dent. 2020 Dec 1;44(6):436-441. doi: 10.17796/1053-4625-44.6.8.
Plasma cell granuloma (PCG) is a rare benign pseudotumorous proliferation of unclear etiology that is mainly situated in the lungs. Gingival PCG is an even more peculiar lesion that usually occurs in middle-aged or elderly individuals and clinically manifests as a solitary entity.
A 15-year-old male with no underlying medical conditions presented with multiple gingival masses in the right maxilla, which were initially thought to be epulis. The lesions were resected completely and the excisional biopsies sent for histological examination. Immunohistochemical (IHC) stain revealed dense polyclonal plasma cell infiltration with positive expression of both kappa and lambda light chains, confirming a diagnosis of gingival PCG. Subsequently, the affected gingiva healed uneventfully, with no sign of recurrence over 2 years of follow-up.
The present report depicts an extremely unusual case of gingival PCG occurring in a juvenile with multiple lesions, which is worth attention in clinical pediatric dentistry. Excisional-biopsy and histological investigations are imperative for a confirmative diagnosis and to exclude potential aggressive conditions. Complete resection of lesions seems to be a valid treatment, while long-term clinical follow-up is still needed.
浆细胞肉芽肿（PCG）是一种罕见的良性假肿瘤性增生，病因不明，主要发生在肺部。牙龈 PCG 是一种更为特殊的病变，通常发生在中年或老年人群中，临床上表现为单发实体。
一名 15 岁男性，无潜在疾病，右上颌出现多个牙龈肿块，最初被认为是牙龈瘤。病变被完全切除，并对切除活检进行组织学检查。免疫组织化学（IHC）染色显示密集的多克隆浆细胞浸润，κ 和 λ 轻链均呈阳性表达，确诊为牙龈 PCG。随后，受影响的牙龈愈合良好，2 年随访无复发迹象。
本报告描述了一例青少年多发病变的极不寻常的牙龈 PCG 病例，值得临床儿科牙医关注。切除活检和组织学检查对于明确诊断和排除潜在侵袭性疾病至关重要。病变的完全切除似乎是一种有效的治疗方法，同时仍需要长期的临床随访。
