Dayie Nicholas Tkd, Sekoh Deborah Nk, Tetteh-Quarcoo Patience B, Dayie Alberta D, Osei Mary-Magdalene, Kotey Fleischer Cn, Donkor Eric S
Department of Medical Microbiology, University of Ghana Medical School, Accra, Ghana.
FleRhoLife Research Consult, Teshie, Accra, Ghana.
Microbiol Insights. 2022 Oct 31;15:11786361221133959. doi: 10.1177/11786361221133959. eCollection 2022.
Sickle cell disease (SCD) patients are an important risk group for () carriage and infections. Little is, however, known about the nasopharyngeal carriage epidemiology of the pathogen in this vulnerable population.
The aim of this study was to evaluate and methicillin-resistant (MRSA) nasopharyngeal carriage prevalence, carriage determinants, and antimicrobial resistance among SCD adults in Ghana.
Nasopharyngeal swabs, obtained from 200 SCD adults recruited at the Korle Bu Teaching Hospital, were cultured for , and these isolates were subjected to antimicrobial susceptibility testing via the Kirby-Bauer method.
The prevalence of carriage was 41.5% (n = 83), and that of MRSA carriage was 1.0% (n = 2). Moreover, carriage of coagulase-negative (CoNS) was the only determinant of carriage identified (OR = 0.012, < .0001). However, neither this variable nor the other features of the participants emerged as a determinant of MRSA carriage. The antimicrobial resistance rates decreased across penicillin (98.8%, n = 82), tetracycline (54.2%, n = 45), gentamicin (32.5%, n = 27), ciprofloxacin (21.7%, n = 18), erythromycin (18.1%, n = 15), clindamycin (10.8%, n = 9), amoxicillin-clavulanic acid (10.8%, n = 9), teicoplanin (1.2%, n = 1), and linezolid (0.0%, n = 0), and the multidrug resistance rate was 45.8% (n = 38).
The nasopharyngeal carriage prevalence of in the current study was high, while that of MRSA was low. The isolates were highly resistant to several of the antibiotics tested, but not teicoplanin and linezolid, making these antibiotics suitable for treatment of infections among the SCD population.
镰状细胞病（SCD）患者是携带（）和感染的重要风险群体。然而，对于该脆弱人群中病原体的鼻咽部携带流行病学了解甚少。
本研究旨在评估加纳SCD成年患者中（）和耐甲氧西林金黄色葡萄球菌（MRSA）的鼻咽部携带率、携带决定因素及抗菌药物耐药性。
从科勒布教学医院招募的200名SCD成年患者中获取鼻咽拭子，培养（），并通过 Kirby-Bauer 法对这些分离株进行抗菌药物敏感性测试。
（）携带率为41.5%（n = 83），MRSA携带率为1.0%（n = 2）。此外，凝固酶阴性葡萄球菌（CoNS）携带是唯一确定的（）携带决定因素（OR = 0.012，P <.0001）。然而，该变量及参与者的其他特征均未成为MRSA携带的决定因素。青霉素（98.8%，n = 82）、四环素（54.2%，n = 45）、庆大霉素（32.5%，n = 27）、环丙沙星（21.7%，n = 18）、红霉素（18.1%，n = 15）、克林霉素（10.8%，n = 9）、阿莫西林-克拉维酸（10.8%，n = 九）、替考拉宁（1.2%，n = 1）和利奈唑胺（0.0%，n = 0）的抗菌药物耐药率下降，多重耐药率为45.8%（n = 三十八）。
本研究中（）的鼻咽部携带率较高，而MRSA的携带率较低。分离株对几种测试抗生素高度耐药，但对替考拉宁和利奈唑胺不耐药，使这些抗生素适用于治疗SCD人群中的（）感染。
