Ho Wen-Tsao, Yang Chin-Yi, Tsai Ming-Feng
Department of Dermatology, Ho Wen Tsao Skin Clinic, New Taipei City, 244, Taiwan.
Department of Dermatology, New Taipei Municipal TuCheng Hospital, New Taipei City, 236, Taiwan.
Clin Cosmet Investig Dermatol. 2022 Oct 30;15:2335-2343. doi: 10.2147/CCID.S381380. eCollection 2022.
Many patients with axillary osmidrosis (AO) cannot tolerate the local irritation of strong antiperspirants and discontinue AO use within a short time. This study evaluates the effect of long-term antiperspirant use on postoperative complications after osmidrosis surgery.
A total of 116 females (66 antiperspirant and 50 non-antiperspirant cases) who underwent osmidrosis surgery were retrospectively reviewed. Postoperative complications were compared between the 2 groups.
Patients with long-term antiperspirant use had a lower risk of full-thickness skin necrosis compared with those who did not use antiperspirants (odds ratio [OR] = 0.048, 95% confidence Interval [CI]: 0.006-0.392, p = 0.005). Patients with antiperspirants use also had a lower risk of moderate-to-severe erythema compared to those without antiperspirants use (moderate vs mild erythema: OR = 0.351, 95% CI: 0.129-0.959, p = 0.041; severe vs mild erythema: OR = 0.161, 95% CI: 0.047-0.550, p = 0.004). Patients who used antiperspirants also had a lower risk of severe skin erosion compared to those who did not use antiperspirants (severe vs mild skin erosion: OR = 0.164, 95% CI: 0.037-0.725, p = 0.017). There was a trend of lower risk in moderate skin erosion in patients with antiperspirant use compared to those without antiperspirant use, but it was not statistically significant (moderate vs mild epidermal damage and peeling: OR = 0.406, 95% CI: 0.158-1.043, p = 0.061).
Postoperative complications in patients with AO who undergo osmidrosis surgery are lower in those with a long-term antiperspirant use compared to patients who did not use antiperspirants.
许多腋臭（AO）患者无法耐受强力止汗剂的局部刺激，并在短时间内停止使用。本研究评估长期使用止汗剂对腋臭手术后术后并发症的影响。
回顾性分析116例行腋臭手术的女性患者（66例使用止汗剂，50例未使用止汗剂）。比较两组的术后并发症。
与未使用止汗剂的患者相比，长期使用止汗剂的患者发生全层皮肤坏死的风险更低（比值比[OR]=0.048，95%置信区间[CI]：0.006 - 0.392，p = 0.005）。与未使用止汗剂的患者相比，使用止汗剂的患者发生中度至重度红斑的风险也更低（中度红斑与轻度红斑：OR = 0.351，95% CI：0.129 - 0.959，p = 0.041；重度红斑与轻度红斑：OR = 0.161，95% CI：0.047 - 0.550，p = 0.004）。与未使用止汗剂的患者相比，使用止汗剂的患者发生严重皮肤糜烂的风险也更低（严重皮肤糜烂与轻度皮肤糜烂：OR = 0.164，95% CI：0.037 - 0.725，p = 0.017）。与未使用止汗剂的患者相比，使用止汗剂的患者发生中度皮肤糜烂的风险有降低趋势，但差异无统计学意义（中度皮肤糜烂与轻度表皮损伤及脱皮：OR = 0.406，95% CI：0.158 - 1.043，p = 0.061）。
与未使用止汗剂的患者相比，长期使用止汗剂的腋臭患者在接受腋臭手术后的术后并发症更低。
