Dermatologikum Hamburg GmbH, Hamburg, Germany.
Department of Dermatology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Dermatol Ther. 2021 Jul;34(4):e15020. doi: 10.1111/dth.15020. Epub 2021 Jun 29.
Aluminium chloride-based antiperspirants are an effective topical therapeutic option for mild to moderate states of excessive perspiration. Its use is primarily limited by the occurrence of skin irritation, especially in sensitive skin types. The objective of this study was to compare the antiperspirant efficacy and tolerability of a novel antiperspirant with 12.5% aluminium lactate, and a 12.5% aluminium chloride-based antiperspirant. This cohort study was conducted as a two-sided self-assessment comparison between both preparations in healthy volunteers to generate selfcare-related data. Almost half of the participants stated that aluminium chloride was more efficacious than aluminium lactate; 22% stated aluminium lactate was more efficacious than aluminium chloride; 28% observed no difference in the efficacy of both preparations (p = 0.04). However, 88% described greater tolerability with aluminium lactate (p < 0.0001). In this study, aluminium lactate showed significantly greater tolerability than aluminium chloride, although the latter tended to show slightly greater efficacy.
基于氯化铝的止汗剂是治疗轻中度过度出汗的有效局部治疗选择。其使用主要受到皮肤刺激的发生限制，特别是在敏感皮肤类型中。本研究的目的是比较新型含 12.5%乳酸铝和 12.5%氯化铝的止汗剂的止汗效果和耐受性。这项队列研究是在健康志愿者中进行的，采用双侧自我评估比较两种制剂，以生成自我护理相关数据。近一半的参与者表示氯化铝比乳酸铝更有效；22%的参与者表示乳酸铝比氯化铝更有效；28%的参与者观察到两种制剂的疗效没有差异（p=0.04）。然而，88%的参与者表示乳酸铝的耐受性更好（p<0.0001）。在这项研究中，乳酸铝的耐受性明显优于氯化铝，尽管后者的疗效略有增加。
