Jhatial Mussadique Ali, Bin Naeem Sameen, Abbas Mansoor, Baloch Naqib Ullah, Bokhari Syed W, Ahsan Bushra, Ahmad Usman, Masood Sheikh Rizwan
Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.
Medical Oncology, Shaukat Khanum Memoiral Cancer Hospital and Research Centre, Lahore, PAK.
Cureus. 2022 Sep 30;14(9):e29785. doi: 10.7759/cureus.29785. eCollection 2022 Sep.
Bleomycin is a commonly used cytotoxic agent that has proven its efficacy over the years. Though a common part of many protocols targeting lymphomas and germ cell tumors, it does have some serious adverse effects. Bleomycin is notorious for pulmonary toxicity and very rarely may cause fulminant hyperpyrexia. We describe two cases of classical Hodgkin's lymphoma (cHL) developing acute fulminant hyperpyrexia after administration of the first dose of bleomycin as part of chemotherapy protocol. This is a rare adverse reaction that closely mimics anaphylaxis and has an unpredictable and possibly fatal course. Health care professionals involved in the administration of chemotherapy need to be very vigilant in monitoring for symptoms of this reaction.
博来霉素是一种常用的细胞毒性药物，多年来已证明其疗效。尽管它是许多针对淋巴瘤和生殖细胞肿瘤方案的常见组成部分，但确实有一些严重的不良反应。博来霉素因肺毒性而声名狼藉，极少数情况下可能导致暴发性高热。我们描述了两例经典型霍奇金淋巴瘤（cHL）患者，在作为化疗方案的一部分给予首剂博来霉素后发生急性暴发性高热。这是一种罕见的不良反应，与过敏反应极为相似，且病程不可预测，可能致命。参与化疗给药的医护人员在监测这种反应的症状时需要非常警惕。
