Ma D D, Isbister J P
Cancer. 1980 May 1;45(9):2249-51. doi: 10.1002/1097-0142(19800501)45:9<2249::aid-cncr2820450905>3.0.co;2-6.
Two cases of fulminant hyperpyrexia induced by cytotoxic agents (bleomycin in a patient with lymphoma, and daunorubicin in a patient with acute myeloblastic leukemia) are presented. Each patient had a fever greater than 42 degrees C, with a shock-like reaction and coma. Evidence of disseminated intravascular coagulopathy developed in the patient with bleomycin-induced hyperpyrexia and she died 24 hours afterwards. The pathogenesis and management of hyperpyrexial reactions to cytotoxic drugs are discussed.
本文报告了两例由细胞毒性药物引起的暴发性高热病例（一例为淋巴瘤患者使用博来霉素后引发，另一例为急性髓细胞白血病患者使用柔红霉素后引发）。每位患者体温均超过42摄氏度，伴有类似休克的反应和昏迷。使用博来霉素诱发高热的患者出现了弥散性血管内凝血的证据，24小时后死亡。本文还讨论了细胞毒性药物引起的高热反应的发病机制及处理方法。
