载多柔比星和艾拉菌素的纳米金胶束逆转乳腺癌耐药性。
Nano-gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer.
机构信息
Department of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Department of Dentistry, Second Hospital Affiliated to Tianjin Medical University, Tianjin, China.
出版信息
IET Nanobiotechnol. 2023 Apr;17(2):49-60. doi: 10.1049/nbt2.12102. Epub 2022 Nov 7.
The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug-resistant in breast cancer cells. Nano-gold micelles loaded with Dox and Elacridar (FP-ssD@A-E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP-ssD@A-E gradually increased, and the drug loading rate gradually decreased. FP-ss@A-E had a sustained-release effect. Dox, Elacridar, FP-ss@AuNPs, and FP-ssD@A-E significantly improved cell apoptosis, in which, FP-ssD@A-E was the most significant. FP-ssD@A-E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR-1, P-gp, IL-6, and i-NOS were significantly decreased after Dox, Dox + Elacridar, FP-ss@AuNPs, and FP-ssD@A-E treatment. It was worth noting that FP-ssD@A-E had the most significant effects. The prepared FP-ssD@A-E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency.
本研究旨在为挽救乳腺癌细胞耐药性的敏感性提供一种新的有效载体。通过化学合成载有多柔比星（Dox）和 Elacridar（FP-ssD@A-E）的纳米金胶束。随着 Dox 和 Elacridar 用量的增加，FP-ssD@A-E 的包封率逐渐增加，载药量逐渐降低。FP-ss@A-E 具有持续释放效果。Dox、Elacridar、FP-ss@AuNPs 和 FP-ssD@A-E 均显著促进细胞凋亡，其中 FP-ssD@A-E 效果最为显著。FP-ssD@A-E 显著降低了细胞活力并提高了 Dox 的摄取量。Dox、Dox+Elacridar、FP-ss@AuNPs 和 FP-ssD@A-E 处理后，VEGFR-1、P-gp、IL-6 和 i-NOS 的水平均显著降低，其中 FP-ssD@A-E 的效果最为显著。所制备的 FP-ssD@A-E 胶束呈球形，粒径分布均匀，具有良好的载药性能和包封效率。
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