Zheng JinLing, Meng DanDan, Zheng Xing, Zhang Yan, Chen HongFei
University of South China, No. 28 Changshengxi Road, Hunan 421001, China.
University of South China, No. 28 Changshengxi Road, Hunan 421001, China.
Int J Pharm. 2021 Jun 15;603:120644. doi: 10.1016/j.ijpharm.2021.120644. Epub 2021 May 6.
Breast cancer is one of the most common malignant tumors among women population on a global scale, with a huge number of new cases and deaths each year. In recent years, there has been an increasing number of literatures on the discovery and development of novel anti-breast cancer drugs and materials, aiming to increase the survival rate of breast cancer patients. One of the newest tools used for the therapy of breast cancer is graphene-based materials, which have ultra-high surface area as well as unique physical, chemical and mechanical properties. It is reported that graphene-based materials could induce apoptosis in cancer cells while showing low toxicity due to their carbon structure. Therefore, they can be used as nano-drugs or biological carriers to introduce small molecules such as nucleic acids, drugs, or photosensitizers into the human body to achieve treatment goals. This article introduces the synthetic methods for graphene-based materials, as well as the current status and the future prospects of graphene-based materials' application in the treatment of breast cancer.
乳腺癌是全球女性群体中最常见的恶性肿瘤之一，每年有大量新发病例和死亡病例。近年来，关于新型抗乳腺癌药物和材料的发现与开发的文献越来越多，旨在提高乳腺癌患者的生存率。用于乳腺癌治疗的最新工具之一是基于石墨烯的材料，其具有超高的表面积以及独特的物理、化学和机械性能。据报道，基于石墨烯的材料能够诱导癌细胞凋亡，同时因其碳结构而显示出低毒性。因此，它们可用作纳米药物或生物载体，将核酸、药物或光敏剂等小分子引入人体以实现治疗目标。本文介绍了基于石墨烯的材料的合成方法，以及基于石墨烯的材料在乳腺癌治疗中的应用现状和未来前景。
