Center of Excellence for Genome and Cancer Research, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Redox Rep. 2022 Dec;27(1):249-258. doi: 10.1080/13510002.2022.2139947.
To investigate the renoprotective, the antioxidant, and the anti-inflammatory impact of a combination of SPL and ZnO-NPs to combat against chronic kidney disease (CKD).
In total, 50 males of rats were distributed into 5 groups (10 rats each); normal group, adenine sulfate (0.25% in diet for 10 days) (CKD) group. After the last dose of adenine sulfate, rats were divided into three groups: SPL + Adenine sulfate group; rats were treated orally by mixing SPL (20 mg/kg/day) into chow for 8 weeks, ZnO-NPs + Adenine sulfate group; rats were injected intraperitoneally with ZnO-NPs (5 mg/kg) three times weekly for 8 weeks, ZnO-NPs + SPL + Adenine sulfate group; rats were injected with the same previous doses for 8 weeks.
Each of SPL and ZnO-NPs up-regulated antioxidant genes ( and ), down-regulated fibrotic and inflammatory genes (, and ) compared to CKD. Furthermore, a combination of SPL and ZnO-NPs resulted in a greater improvement in the measured parameters than a single treatment.
The therapeutic role of SPL was enhanced by the antioxidant and the anti-inflammatory role of ZnO-NPs, which presented a great renoprotective effect against CKD.
研究 SPL 和 ZnO-NPs 联合应用对慢性肾脏病（CKD）的肾保护、抗氧化和抗炎作用。
将 50 只雄性大鼠随机分为 5 组（每组 10 只）：正常组、硫酸腺嘌呤（饮食中 0.25%，10 天）（CKD）组。给予最后一次硫酸腺嘌呤后，将大鼠分为 3 组：SPL+硫酸腺嘌呤组；大鼠每天通过混合 SPL（20mg/kg）到饲料中进行口服治疗 8 周；ZnO-NPs+硫酸腺嘌呤组；每周三次腹膜内注射 ZnO-NPs（5mg/kg），共 8 周；ZnO-NPs+SPL+硫酸腺嘌呤组；大鼠以相同的剂量治疗 8 周。
与 CKD 相比，SPL 和 ZnO-NPs 均能上调抗氧化基因（和），下调纤维化和炎症基因（、和）。此外，与单一治疗相比，SPL 和 ZnO-NPs 的联合治疗对各项参数的改善效果更大。
ZnO-NPs 的抗氧化和抗炎作用增强了 SPL 的治疗作用，对 CKD 具有很好的肾保护作用。
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