The ability of D-dimer, albumin, and D-Dimer/albumin ratio to predict in-hospital mortality and intensive care unit admission in COVID-19 patients admitted to the emergency department.

OBJECTIVES

COVID-19 can also cause multi-organ failure or severe pneumonia. Therefore, new biomarkers are being investigated for rapid diagnosis, early treatment and reduced mortality rates. In this study, D-dimer and albumin were looked at from a different perspective.

BACKGROUND

We think that D-dimer/Albumin ratio (DAR), D-dimer and albumin may be parameters that can be used to predict in-hospital mortality and intensive care unit admission in COVID-19 patients.

METHODS

The patients included in the study were divided into 2 groups according to their hospitalization status in the service and intensive care unit. These two groups were compared in terms of DAR, other laboratory data and in-hospital mortality.

RESULTS

The primary findings we obtained are as follows: (1) DAR and D-dimer values are higher in patients who died in-hospital, and albumin values are lower than those who survived; (2) D-dimer and DAR median values are significantly higher in the intensive care group than in the service group. Albumin was significantly lower in the intensive care group; (3) D-dimer, albumin and DAR predicting in-hospital mortality, respectively: D-Dimer's sensitivity 56 % and specificity 57 %, albumin's sensitivity 70 % and specificity 53 %, DAR's sensitivity 56 %, specificity is 58 %; (4) The parameter with the highest predictive power for intensive care admission is albumin.

CONCLUSION

Although albumin had the highest sensitivity values in determining mortality or predicting intensive care admission in our study, we think that D-dimer and DAR may be other parameters to be used to predict intensive care admission and in-hospital mortality (Tab. 5, Fig. 2, Ref. 19) Keywords: COVID-19, albumin, D-dimer, mortality, D-dimer/albumin.