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荆条在乳房疼痛中作用的潜在机制。

The mechanisms underlying the role of Vitex agnus-castus in mastalgia.

作者信息

Zeqiri Aurel, Dermaku-Sopjani Miribane, Sopjani Mentor

出版信息

Bratisl Lek Listy. 2022;123(12):913-918. doi: 10.4149/BLL_2022_147.

DOI:10.4149/BLL_2022_147
PMID:36342880
Abstract

Medicinal plants exert therapeutic effects or have beneficial healing functions on the human or animal body. Medicinal plants are widely used in traditional medicine as an interesting alternative and/or complementary to science-based medicine. Compared to chemical drugs, medicinal plants have a lower risk of side effects, are eco-friendly, and have cost-effective production. This encouraged researchers to extensively exploit them for their therapeutic use. One of the most well-known medicinal plants is Vitex agnus-castus L., which belongs to the Verbenaceae family. This shrub tree is mainly grown in tropical and sub-tropical regions. The parts of VAC, especially berries and leaves, contain essential oils, flavonoids, and diterpenes. Many medical benefits of VAC have already been reported, including mastalgia, regulating menstrual cycles and premenstrual complaints, and infertility. Respiratory and cardiovascular effects are also reported. In this review, we will analyze and characterize the known roles of VAC in mastalgia, as well as the mechanism of action reported in in vitro and/or in vivo studies, and show the potential for alternative therapeutic uses in mastalgia, also known as breast pain (Fig. 2, Ref. 40). Keywords: mastalgia, Vitex agnus-castus, therapy, traditional medicine.

摘要

药用植物对人体或动物体具有治疗作用或有益的愈合功能。药用植物在传统医学中被广泛用作基于科学的医学的有趣替代和/或补充。与化学药物相比,药用植物副作用风险较低,生态友好,生产成本效益高。这鼓励研究人员广泛开发它们用于治疗用途。最著名的药用植物之一是马鞭草科的贞节树。这种灌木树主要生长在热带和亚热带地区。贞节树的各个部位,尤其是浆果和叶子,含有精油、黄酮类化合物和二萜类化合物。贞节树的许多医学益处已经被报道,包括乳房疼痛、调节月经周期和经前不适以及不孕症。也有关于其呼吸和心血管作用的报道。在本综述中,我们将分析和描述贞节树在乳房疼痛中的已知作用,以及体外和/或体内研究中报道的作用机制,并展示其在乳房疼痛(也称为乳腺疼痛)中替代治疗用途的潜力(图2,参考文献40)。关键词:乳房疼痛;贞节树;治疗;传统医学。

相似文献

1
The mechanisms underlying the role of Vitex agnus-castus in mastalgia.荆条在乳房疼痛中作用的潜在机制。
Bratisl Lek Listy. 2022;123(12):913-918. doi: 10.4149/BLL_2022_147.
2
Use of Vitex agnus-castus in patients with menstrual cycle disorders: a single-center retrospective longitudinal cohort study.贞节树用于月经周期紊乱患者:一项单中心回顾性纵向队列研究。
Arch Gynecol Obstet. 2024 May;309(5):2089-2098. doi: 10.1007/s00404-023-07363-4. Epub 2024 Feb 23.
3
Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus.贞节树对经前、经后及不孕疾病影响的系统评价
Electron Physician. 2017 Jan 25;9(1):3685-3689. doi: 10.19082/3685. eCollection 2017 Jan.
4
Identification of New Diterpenes as Putative Marker Compounds Distinguishing Agnus Castus Fruit (Chaste Tree) from Shrub Chaste Tree Fruit (Viticis Fructus).鉴定新的二萜类化合物作为区分贞洁果(荆条果实)和蔓荆子果实的潜在标志物化合物。
Planta Med. 2016 Jan;82(1-2):147-53. doi: 10.1055/s-0035-1558089. Epub 2016 Jan 12.
5
Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis.蔓荆子治疗周期性乳房痛:系统评价和荟萃分析。
J Womens Health (Larchmt). 2020 Feb;29(2):262-278. doi: 10.1089/jwh.2019.7770. Epub 2019 Aug 29.
6
Effects of Vitex agnus and Flaxseed on cyclic mastalgia: A randomized controlled trial.牡荆和亚麻籽对周期性乳房疼痛的影响:一项随机对照试验。
Complement Ther Med. 2016 Feb;24:90-5. doi: 10.1016/j.ctim.2015.12.009. Epub 2015 Dec 29.
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Vitex agnus castus: a systematic review of adverse events.贞节树:不良事件的系统评价
Drug Saf. 2005;28(4):319-32. doi: 10.2165/00002018-200528040-00004.
8
Vitex agnus-castus safeguards the lung against lipopolysaccharide-induced toxicity in mice.荆条对小鼠肺脏具有保护作用,可抵御脂多糖诱导的毒性。
J Food Biochem. 2019 Mar;43(3):e12750. doi: 10.1111/jfbc.12750. Epub 2018 Dec 13.
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Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications.贞节树(蔓荆子)——药理学与临床适应症
Phytomedicine. 2003 May;10(4):348-57. doi: 10.1078/094471103322004866.
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Can Vitex Agnus Castus be Used for the Treatment of Mastalgia? What is the Current Evidence?蔓荆子可否用于治疗乳房痛?现有证据如何?
Evid Based Complement Alternat Med. 2008 Sep;5(3):247-50. doi: 10.1093/ecam/nem074.

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