School of Psychology, Shaanxi Normal University, Xi'an, China.
School of Psychology, Shaanxi Normal University, Xi'an, China.
Neuropsychologia. 2022 Dec 15;177:108414. doi: 10.1016/j.neuropsychologia.2022.108414. Epub 2022 Nov 5.
The present study aimed to investigate the role of connectivity disruptions in two fiber pathways, the uncinate fasciculus (UF) and the frontal aslant tract (FAT), in developmental dyslexia and determine the relationship between the connectivity of these pathways and behavioral performance in children with dyslexia. A total of 26 French children with dyslexia and 31 age-matched control children were included. Spherical deconvolution tractography was used to reconstruct the two fiber pathways. Hindrance-modulated oriented anisotropy (HMOA) was used to measure the connectivity of each fiber pathway in both hemispheres. Only boys with dyslexia showed reduced HMOA in the UF compared to control boys. Furthermore, HMOA of the UF correlated with individual differences in the visual attention span in participants with dyslexia. All significant results found in HMOA of the UF were verified in fractional anisotropy (FA) of the UF using standard diffusion imaging model. This study suggests a differential sex effect on the connectivity disruption in the UF in developmental dyslexia. It also indicates that the UF may play an essential role in the visual attention span deficit in developmental dyslexia.
本研究旨在探讨两条纤维束——钩束（UF）和额斜束（FAT）——连接中断在发展性阅读障碍中的作用，并确定这些通路的连接与阅读障碍儿童行为表现之间的关系。共纳入 26 名法国阅读障碍儿童和 31 名年龄匹配的对照组儿童。使用球谐分解轨迹重建两条纤维束。使用阻碍调制各向异性（HMOA）测量每个纤维束在两个半球的连接。仅阅读障碍的男孩与对照组男孩相比，UF 中的 HMOA 降低。此外，阅读障碍者 UF 的 HMOA 与参与者视觉注意力跨度的个体差异相关。UF 的 HMOA 中发现的所有显著结果均使用标准扩散成像模型在 UF 的分数各向异性（FA）中得到验证。本研究表明，在发展性阅读障碍中，UF 的连接中断存在性别差异。这也表明 UF 在发展性阅读障碍的视觉注意力跨度缺陷中可能起着重要作用。
