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内皮和内皮下层的前列环素样活性——对动脉粥样硬化很重要吗？

Prostacyclin-like activity of endothelium and subendothelium - important for atherosclerosis?

作者信息

Silberbauer K, Sinzinger H, Winter M, Feigl W, Ring F

出版信息

Experientia. 1978 Nov 15;34(11):1471-2. doi: 10.1007/BF01932360.

DOI:10.1007/BF01932360
PMID:363442
Abstract

Morphological control of Moncada's bioassay for prostacyclin (PG I2) activity measurement shows that the activity depends not only on endothelium, but in important amounts on subendothelial tissue too. Therefore, it can be concluded that platelet thrombus formation after endothelial cell injury does not depend only on the PG I2-producing ability of the tissue.

摘要

用于测量前列环素（PG I2）活性的蒙卡达生物测定法的形态学控制表明，该活性不仅取决于内皮，而且在很大程度上也取决于内皮下组织。因此，可以得出结论，内皮细胞损伤后血小板血栓形成不仅取决于组织产生PG I2的能力。

相似文献

1
Prostacyclin-like activity of endothelium and subendothelium - important for atherosclerosis?内皮和内皮下层的前列环素样活性——对动脉粥样硬化很重要吗？
Experientia. 1978 Nov 15;34(11):1471-2. doi: 10.1007/BF01932360.
2
[Effect of heparin on prostacyclin activity of the aorta wall].
Biull Eksp Biol Med. 1982 Sep;94(9):79-80.
3
Prostacyclin (prostaglandin I2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium.
Blood. 1979 Feb;53(2):244-50.
4
Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium.
Prostaglandins. 1978 Jul;16(1):17-22. doi: 10.1016/0090-6980(78)90197-1.
5
Contribution of a platelet component to endothelial prostacyclin production despite inhibition of platelet cyclooxygenase activity.尽管血小板环氧合酶活性受到抑制，但血小板成分对内皮前列环素生成仍有贡献。
Trans Assoc Am Physicians. 1982;95:272-9.
6
Platelet adhesion and mural platelet thrombus formation on aortic subendothelium of rats, rabbits, and guinea pigs correlate negatively with the vascular PGI2 production.大鼠、兔和豚鼠主动脉内皮下的血小板黏附和壁血小板血栓形成与血管前列环素（PGI2）的产生呈负相关。
J Lab Clin Med. 1981 Sep;98(3):402-11.
7
Effect of insulin treatment on prostacyclin in experimental diabetes.胰岛素治疗对实验性糖尿病中前列环素的影响。
Diabetologia. 1980 Jan;18(1):65-8. doi: 10.1007/BF01228305.
8
Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart.前列环素是从离体灌注的兔和大鼠心脏释放的主要前列腺素。
Nature. 1977 Jul 14;268(5616):160-3. doi: 10.1038/268160a0.
9
Enhanced release of a 'prostacyclin-like' substance from aortic strips of spontaneously hypertensive rats.
Prostaglandins. 1980 Feb;19(2):285-9. doi: 10.1016/0090-6980(80)90026-x.
10
Prostacyclin (PGI2)-generation by different types of human atherosclerotic lesions.不同类型人类动脉粥样硬化病变产生前列环素（PGI2）的情况。
Exp Pathol (Jena). 1980;18(3):175-80. doi: 10.1016/s0014-4908(80)80018-4.

引用本文的文献

1
Prostaglandin I2 (prostacyclin).前列腺素I2（前列环素）。
Can Med Assoc J. 1980 Jan 26;122(2):175-9.
2
Coronary vasoconstrictor and vasodilator actions of arachidonic acid in the isolated perfused heart of the rat.花生四烯酸在大鼠离体灌流心脏中的冠状动脉收缩和舒张作用。
Br J Pharmacol. 1982 Feb;75(2):269-86. doi: 10.1111/j.1476-5381.1982.tb08783.x.
3
Relation between fibrinolytic activity and prostacyclin generation of atherosclerotic artery and dacron prosthetic graft.动脉粥样硬化动脉与涤纶人工血管的纤溶活性和前列环素生成之间的关系。

本文引用的文献

1
The role of endothelial injury in arterial thrombosis and atherogenesis.内皮损伤在动脉血栓形成和动脉粥样硬化中的作用。
Adv Cardiol. 1970;4:67-71. doi: 10.1159/000387605.
2
Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog). A comparative study.哺乳动物（人类、大鼠、兔子、豚鼠、马、狗）的血小板聚集。一项比较研究。
Thromb Diath Haemorrh. 1967 Feb 28;17(1-2):99-111.
3
Experimental aortic intimal thickening. I. Morphology and source of intimal cells.实验性主动脉内膜增厚。I. 内膜细胞的形态学及来源
Experientia. 1979 Jun 15;35(6):785-6. doi: 10.1007/BF01968247.
Am J Pathol. 1974 Aug;76(2):245-64.
4
The subendothelium and thrombogenesis.内皮下层与血栓形成。
Bull N Y Acad Med. 1972 Feb;48(2):289-301.
5
Repair in arterial tissue. A scanning electron microscopic (SEM) and light microscopic study on the endothelium of rabbit thoracic aorta following a single dilatation injury.动脉组织的修复。对兔胸主动脉单次扩张损伤后内皮进行的扫描电子显微镜（SEM）和光学显微镜研究。
Virchows Arch A Pathol Pathol Anat. 1973 Aug 9;360(2):93-106.
6
Quantitative morphological investigations on smooth muscle cells in vascular surgical specimens and their clinical importance.血管手术标本中平滑肌细胞的定量形态学研究及其临床意义。
Experientia. 1975 Nov 15;31(11):1352-4. doi: 10.1007/BF01945822.
7
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.脂质过氧化物会抑制血管微粒体中的一种酶，该酶能从前列腺素内过氧化物生成一种可防止血小板聚集的物质（前列腺素X）。
Prostaglandins. 1976 Nov;12(5):715-37. doi: 10.1016/0090-6980(76)90048-4.
8
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.动脉壁可通过一种由前列腺素内过氧化物生成的物质（前列腺素X）来防止血小板血栓的沉积。
Prostaglandins. 1976 Nov;12(5):685-713. doi: 10.1016/0090-6980(76)90047-2.
9
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.从动脉中分离出的一种酶可将前列腺素内过氧化物转化为一种抑制血小板聚集的不稳定物质。
Nature. 1976 Oct 21;263(5579):663-5. doi: 10.1038/263663a0.
10
Some investigations into the role of prostacyclin in thromboregulation.关于前列环素在血栓调节中作用的一些研究。
Thromb Res. 1978 Feb;12(2):367-74. doi: 10.1016/0049-3848(78)90308-0.