慢性外阴裂伤：使用交联透明质酸治疗。
Chronic vulvar fissure: approach with cross-linked hyaluronic acid.
机构信息
DIATROS, Woman's Clinic. Gynecology and Obstetrics, Teknon Medical Center, Barcelona, Spain.
Private Practice, Pereira, Colombia.
出版信息
Int Urogynecol J. 2023 Jul;34(7):1495-1499. doi: 10.1007/s00192-022-05401-4. Epub 2022 Nov 7.
INTRODUCTION AND HYPOTHESIS
This report aims to prospectively describe the effectiveness and safety of injected cross-linked hyaluronic acid (HA) for the treatment of chronic vulvar fissures.
METHODS
A descriptive prospective case series design including 15 patients affected by chronic vulvar fissures who were treated with cross-linked HA filler between December 2020 and July 2021. The validated 21-item Vulvovaginal Symptoms Questionnaire (VSQ) was used to evaluate the results from baseline up to 9 months after the HA infiltration.
RESULTS
A total of 15 patients suffering from chronic vulvar fissures were treated with an injection of 19 mg/mL HA filler. We found a significant improvement in VSQ scores at the end of the treatment compared to baseline. Patients reported excellent tolerance of the procedure, and no complications were recorded.
CONCLUSIONS
Cross-linked HA infiltration of the vulvar vestibule and posterior vaginal wall appeared to be a promising approach for chronic vulvar fissures.
引言与假设
本报告旨在前瞻性描述交联透明质酸（HA）注射治疗慢性外阴裂伤的有效性和安全性。
方法
一项描述性前瞻性病例系列设计，纳入 2020 年 12 月至 2021 年 7 月期间接受交联 HA 填充剂治疗的 15 例慢性外阴裂伤患者。采用经过验证的 21 项外阴阴道症状问卷（VSQ），评估 HA 渗透治疗前至治疗后 9 个月的结果。
结果
共 15 例慢性外阴裂伤患者接受 19mg/mlHA 填充剂注射治疗。与基线相比，我们发现治疗结束时 VSQ 评分有显著改善。患者报告对该过程具有极好的耐受性，未记录到任何并发症。
结论
交联 HA 外阴前庭和阴道后壁注射似乎是治疗慢性外阴裂伤的一种有前途的方法。
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