交联透明质酸用于第一跖趾关节退变阶段的屈曲改善范围：一项尸体研究

Range of Flexion Improvement in Degenerative Stages of the First Metatarsophalangeal Joint () with Cross-Linked Hyaluronic Acid: A Cadaveric Study.

作者信息

Capell Morera Annabel, de Planell Mas Elena, Perez Palma Laura, Manzanares-Céspedes Maria Cristina

机构信息

Clinical Sciences Department, Faculty of Medicine and Health Sciences, University of Barcelona, 08907 Hospitalet, Spain.

Human Anatomy and Embryology Unit, Experimental Pathology and Therapeutics Department, Faculty of Medicine and Health Sciences, University of Barcelona, 08907 Hospitalet, Spain.

出版信息

J Funct Morphol Kinesiol. 2024 Dec 6;9(4):259. doi: 10.3390/jfmk9040259.

DOI:10.3390/jfmk9040259

PMID:39728243

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11678442/

Abstract

BACKGROUND

Viscosupplementation consists of intraarticular hyaluronic acid injections applied to treat pain and improve joint mobility. The objective of the study was to analyze the improvement of the range of mobility of the first metatarsophalangeal joint with a single dose of cross-linked hyaluronic acid.

METHODS

Ten fresh frozen specimens of feet sectioned below the knee were selected. Before and after the infiltration procedure, the range of flexion was calculated for all specimen's metatarsophalangeal joints. To detect complications due to the procedure, five feet were dissected and five were sectioned with a diamond saw.

RESULTS

The range of the first metatarsophalangeal joint flexion differences between the preoperative and the postoperative period was as follows: (1) 47° (range, 37-51.5) to 58° (range, 49-69.5) degrees of loaded dorsiflexion ( > 0.006); (2) 41° (range, 40-51.5) to 58° (range, 52.5-66.5) degrees of unloaded dorsiflexion ( > 0.009); and (3) 14° (range, 10.5-24.25) to 16° (range, 14.25-28.5) degrees of unloaded plantarflexion ( > 0.083). No injuries of anatomical structures were observed either by anatomical dissection or in the anatomical sections.

CONCLUSIONS

The results obtained in this viscosupplementation study demonstrate the improvement of the range of mobility of the first metatarsophalangeal joint without evidence of extravasation and lesions of the periarticular anatomical structures.

摘要

背景

粘弹性补充疗法包括关节内注射透明质酸，用于治疗疼痛和改善关节活动度。本研究的目的是分析单剂量交联透明质酸对第一跖趾关节活动度的改善情况。

方法

选取10个膝关节以下截断的新鲜冰冻足部标本。在浸润操作前后，计算所有标本跖趾关节的屈曲范围。为检测该操作引起的并发症，对5只脚进行解剖，另外5只用金刚石锯切片。

结果

第一跖趾关节术前与术后屈曲范围的差异如下：(1) 负重背屈从47°（范围37 - 51.5°）至58°（范围49 - 69.5°）（> 0.006）；(2) 非负重背屈从41°（范围40 - 51.5°）至58°（范围52.5 - 66.5°）（> 0.009）；(3) 非负重跖屈从14°（范围10.5 - 24.25°）至16°（范围14.25 - 28.5°）（> 0.083）。无论是解剖观察还是解剖切片，均未观察到解剖结构损伤。