Zabludowicz Center of Autoimmunity, Sheba Medical Center, Tel Hashomer, Israel.
Zabludowicz Center of Autoimmunity, Sheba Medical Center, Tel Hashomer, Israel.
Autoimmun Rev. 2023 Jan;22(1):103230. doi: 10.1016/j.autrev.2022.103230. Epub 2022 Nov 5.
Chronic fatigue syndrome (CFS), fibromyalgia, silicone breast implants syndrome (SBIs), COVID and post-COVID syndrome (PCS), sick building syndrome (SBS), post-orthostatic tachycardia syndrome (POTS), autoimmune diseases and autoimmune/inflammatory syndrome induced by adjuvants (ASIA) are frequently accompanied by clinical symptoms characteristic for dysautonomia: severe fatigue, dizziness, fogginess, memory loss, dry mouth and eyes, hearing dysfunction, tachycardia etc. The recent discovery of an imbalance of autoantibodies against G protein-coupled receptors (GPCR) in some autoimmune diseases, post-COVID syndrome, SBIs allowed researchers to assume the novel mechanism in these conditions - autoimmune autonomic nervous system imbalance. In this review, all data published on an imbalance of autoantibodies against GPCR, clinical symptoms and pathogenic mechanisms in CFS, Fibromyalgia, SBIs, COVID and PCS, SBS, POTS, and some autoimmune diseases were analyzed. Possible criteria to diagnose the autoimmune autonomic nervous system imbalance were created.
慢性疲劳综合征（CFS）、纤维肌痛症、硅酮乳房植入物综合征（SBIs）、COVID 和 COVID 后综合征（PCS）、病态建筑综合征（SBS）、体位性心动过速综合征（POTS）、自身免疫性疾病和疫苗佐剂诱发的自身免疫/炎症综合征（ASIA）常伴有自主神经功能障碍的特征性临床症状：严重疲劳、头晕、混沌、记忆力减退、口干眼干、听力障碍、心动过速等。最近在一些自身免疫性疾病、COVID 后综合征、SBIs 中发现了 G 蛋白偶联受体（GPCR）自身抗体失衡，这使得研究人员假设了这些情况下的新机制——自身免疫性自主神经系统失衡。在这篇综述中，分析了 CFS、纤维肌痛症、SBIs、COVID 和 PCS、SBS、POTS 以及一些自身免疫性疾病中 GPCR 自身抗体失衡、临床症状和发病机制的所有已发表数据。创建了诊断自身免疫性自主神经失衡的可能标准。
