Gastroenterology department, Hospital Professor Doutor Fernando Fonseca, IC 19, 2720-276 Amadora, Portugal.
Internal Medicine department, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal, IC 19, 2720-276 Amadora, Portugal.
Clin Res Hepatol Gastroenterol. 2022 Dec;46(10):102048. doi: 10.1016/j.clinre.2022.102048. Epub 2022 Nov 5.
We report a case series of four patients diagnosed with COVID-19-associated secondary sclerosing cholangitis (SSC), a recently described rare late complication of severe COVID-19. Following prolonged stays in the intensive care unit, these patients developed marked sustained cholestasis and jaundice despite clinical improvement. Cholangiography showed beaded appearance of intra-hepatic bile ducts and bile casts were removed in one patient. None of the patients reached normalization of liver enzymes and at least one progressed to liver cirrhosis (follow-up time of 11 to 16 months). COVID-19-associated SSC has a dismal prognosis with rapid progression to advanced chronic liver disease.
我们报告了四例 COVID-19 相关继发性硬化性胆管炎（SSC）的病例系列，这是一种严重 COVID-19 的罕见迟发性并发症。在重症监护病房长时间住院后，这些患者尽管临床状况改善，但仍出现明显持续的胆汁淤积和黄疸。胆管造影显示肝内胆管呈珠状外观，一名患者取出了胆管铸型。这些患者中没有一人的肝酶恢复正常，至少有一人进展为肝硬化（随访时间为 11 至 16 个月）。COVID-19 相关 SSC 的预后不良，迅速进展为晚期慢性肝病。
