Division of Bioinformatics and Chemical Genomics, Department of System Chemotherapy and Molecular Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan.
J Nat Med. 2023 Jan;77(1):1-11. doi: 10.1007/s11418-022-01662-x. Epub 2022 Nov 8.
Peptidic natural products have received much attention as potential drug leads, and biosynthetic studies of peptidic natural products have contributed to the field of natural product chemistry over the past several decades. However, the key biosynthetic intermediates are generally not isolated from natural sources, and this can hamper a detailed analysis of biosynthesis. Furthermore, reported unusual structures, which are targets for biosynthetic studies, are sometimes the results of structural misassignments. Chemical synthesis techniques are imperative in solving these problems. This review focuses on the chemical syntheses of surugamides and thioamycolamides toward understanding their biosynthesis. These studies can provide the key biosynthetic intermediates that can reveal the biosynthetic pathways and/or true structures of these natural products.
肽类天然产物作为潜在的药物先导物受到了广泛关注，肽类天然产物的生物合成研究在过去几十年中为天然产物化学领域做出了贡献。然而，关键的生物合成中间体通常不能从天然来源中分离出来，这可能会阻碍对生物合成的详细分析。此外，报道的不寻常结构，这些结构是生物合成研究的目标，有时是结构错误分配的结果。化学合成技术在解决这些问题方面至关重要。本文综述了 surugamides 和 thioamycolamides 的化学合成，以了解它们的生物合成。这些研究可以提供关键的生物合成中间体，从而揭示这些天然产物的生物合成途径和/或真实结构。
