一过性磁共振波谱缺血期峰值：卒中后神经发生的一种潜在影像学生物标志物。
A transient magnetic resonance spectroscopy peri-ischemic peak: a possible radiological biomarker of post-stroke neurogenesis.
机构信息
Emergency Department, Stroke Unit, University "La Sapienza", Viale del Policlinico, 155 - 00185, Rome, Italy.
Department of Human Neurosciences, Neuroradiology Unit, University "La Sapienza", Rome, Italy.
出版信息
Neurol Sci. 2023 Mar;44(3):967-978. doi: 10.1007/s10072-022-06479-w. Epub 2022 Nov 9.
BACKGROUND AND AIMS
In adult human brain, neurogenesis seems to persist throughout life and ischemic stroke was proved to stimulate this process. Using magnetic resonance spectroscopy (MRS), a 1.28-ppm peak, putative biomarker of neural progenitor cells (NPCs), was identified both in vitro and in vivo, i.e., in normal rat and healthy human brain. The aim of our study was to identify a 1.28-ppm peak in adult human ischemic brain by using 3.0 T multivoxel MRS.
METHODS
We studied 10 patients, six males, and four females, with a mean (± SD) age of 59.3 (± 17.3), at three different time points from ischemic stroke onset (T0: < 5 days; T14: 14 ± 2 days; T30: 30 ± 2 days).
RESULTS
In all patients except one, a 1.28-ppm peak at T14 was detected at the ischemic boundary (all p values < 0.05). MRS performed on six voluntary age-matched healthy subjects did not detect any 1.28-ppm peak.
CONCLUSIONS
The nature of this 1.28-pm peak is uncertain; however, our data support the hypothesis that it might represent a marker of NPCs in post-stroke human brain.
背景与目的
在成人的大脑中，神经发生似乎贯穿一生，并且缺血性中风已被证明可刺激这一过程。磁共振波谱（MRS）鉴定出了一个 1.28ppm 的峰，该峰被认为是神经祖细胞（NPCs）的生物标志物，在体外和体内，即正常大鼠和健康人类大脑中均有发现。我们的研究旨在使用 3.0T 多体素 MRS 在成人缺血性大脑中鉴定出 1.28ppm 的峰。
方法
我们研究了 10 名患者，男性 6 名，女性 4 名，平均年龄（±标准差）为 59.3（±17.3）岁，在缺血性中风发作后三个不同时间点（T0：<5 天；T14：14±2 天；T30：30±2 天）。
结果
除 1 例患者外，所有患者在 T14 时在缺血边界均检测到 1.28ppm 的峰（所有 p 值均<0.05）。对 6 名年龄匹配的自愿健康受试者进行的 MRS 未检测到任何 1.28ppm 的峰。
结论
该 1.28ppm 峰的性质尚不确定；然而，我们的数据支持这样一种假设，即它可能代表中风后人类大脑中 NPCs 的标志物。
Zotero 插件