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负载于微晶纤维素上的铁酸铜纳米颗粒复合物催化的直接迈克尔加成/脱羧反应：构建3,4-二氢香豆素骨架的一种环保方法

Direct Michael addition/decarboxylation reaction catalyzed by a composite of copper ferrite nanoparticles immobilized on microcrystalline cellulose: an eco-friendly approach for constructing 3,4-dihydrocoumarin frameworks.

作者信息

Kumar Bhupender, Borah Biplob, Babu J Nagendra, Chowhan L Raju

机构信息

School of Applied Material Sciences, Central University of Gujarat, Sector 30 Gandhinagar Gujarat 382021 India

Department of Chemical Sciences, School for Basic and Applied Sciences, Central University of Punjab Ghudda Bathinda 151401 India.

出版信息

RSC Adv. 2022 Oct 27;12(47):30704-30711. doi: 10.1039/d2ra05994k. eCollection 2022 Oct 24.

DOI:10.1039/d2ra05994k
PMID:36349149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9608120/
Abstract

A composite of copper ferrite oxide nanoparticles immobilized on microcrystalline cellulose (CuFeO@MCC) was synthesized. The synthesized composite was characterized by FESEM with EDS-Mapping, TEM, P-XRD, TEM, and BET analysis and investigated for its catalytic activity toward Tandem Michael addition and decarboxylation of coumarin-3-carboxylic acid with cyclic 1,3-diketones to obtain novel 3,4-dihydrocoumarin derivatives. This protocol was established with wide substrate scope and significant yield. The significant characteristics of this methodology are mild reaction conditions, easy setup procedure, non-toxic, and cost-effectiveness. A gram-scale synthesis with low catalyst loading was also demonstrated.

摘要

合成了一种固定在微晶纤维素上的铜铁氧体氧化物纳米颗粒复合材料（CuFeO@MCC）。通过场发射扫描电子显微镜（FESEM）结合能谱分析（EDS-Mapping）、透射电子显微镜（TEM）、粉末X射线衍射（P-XRD）、TEM和比表面积分析（BET）对合成的复合材料进行了表征，并研究了其对香豆素-3-羧酸与环状1,3-二酮的串联迈克尔加成和脱羧反应的催化活性，以获得新型3,4-二氢香豆素衍生物。该方法具有广泛的底物范围和较高的产率。该方法的显著特点是反应条件温和、设置过程简单、无毒且具有成本效益。还展示了低催化剂负载量的克级合成。

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