Mouse Imaging Centre, 25 Orde Street, Toronto, Ontario, Canada.
Translational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
J R Soc Interface. 2022 Nov;19(196):20220579. doi: 10.1098/rsif.2022.0579. Epub 2022 Nov 9.
Fetal growth and maturation are highly intertwined with placental development during pregnancy. Here we used placental vascular morphology measurements (depth and span) as well as the umbilical artery (UA) diameter of previously published studies on three different mouse strains (C57BL6/J, CD-1 and BALB/c), which were exposed to different conditions (combination antiretroviral therapy, chronic maternal hypoxia and malaria infection) at different embryonic days, to test the hypothesis that placental vascularization and specifically the UA size affect conceptus weight. Interaction of each study parameter with embryonic day, strain and exposure to treatments are studied to investigate the stability of the scaling relationships across and/or within strains and conditions. In addition, the effect of UA diameter on the placental growth measurements (depth and span) is studied. These results show that the power-law scaling relationship of conceptus weight and placental depth with the UA diameter is conserved across strains and conditions with the scaling exponent of approximately 3/8 and 5/8, respectively. By contrast, the relationship between conceptus weight and either the placental span or depth is different between strains and conditions, suggesting multiple mechanisms of vascular adaptation.
胎儿的生长和成熟与妊娠期间胎盘的发育高度交织在一起。在这里，我们使用胎盘血管形态学测量值（深度和跨度）以及先前在三种不同小鼠品系（C57BL6 / J、CD-1 和 BALB / c）上发表的研究中的脐动脉（UA）直径，这些品系在不同的胚胎日暴露于不同的条件（联合抗逆转录病毒疗法、慢性母体缺氧和疟疾感染），以检验胎盘血管化，特别是 UA 大小是否会影响胚胎重量的假说。研究了每个研究参数与胚胎日、品系和暴露于处理之间的相互作用，以研究跨品系和条件以及在品系内稳定的比例关系。此外，还研究了 UA 直径对胎盘生长测量值（深度和跨度）的影响。这些结果表明，胚胎重量和胎盘深度与 UA 直径的幂律比例关系在品系和条件之间是保守的，比例指数分别约为 3/8 和 5/8。相比之下，胚胎重量与胎盘跨度或深度之间的关系在不同的品系和条件下是不同的，这表明存在多种血管适应机制。
