Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, 8000 Bahía Blanca, Argentina; Planta Piloto de Ingeniería Química, PLAPIQUI (UNS-CONICET), Camino La Carrindanga Km 7, 8000 Bahía Blanca, Argentina.
Planta Piloto de Ingeniería Química, PLAPIQUI (UNS-CONICET), Camino La Carrindanga Km 7, 8000 Bahía Blanca, Argentina.
Int J Pharm. 2022 Nov 25;628:122353. doi: 10.1016/j.ijpharm.2022.122353. Epub 2022 Oct 29.
The use of 3D printing for the production of systems intended for oral delivery of diet supplements in the veterinary pharmacy constitutes an attractive technology that has remained unexplored. In this sense, this work studies the design and 3D printing of capsular devices that allow the modified release of urea, which is frequently used as a source of non-protein nitrogen in ruminants, but highly toxic if fast ingested. The devices were printed with combinations of polylactic acid (PLA, water-insoluble) and polyvinyl alcohol (PVA, water-soluble) in order to modulate the urea release through the different parts. The optimization of the designs as well as printing parameters such as extrusion temperature, printing speed, retraction distance and nozzle speed resulted critical to obtain successful capsular devices. In addition, the dissolution studies confirmed that the developed designs showed a controlled release of urea, especially the ones that presented internal partitions. Finally, Logistic and Weibull equations were the kinetic models that best fitted the experimental data corresponding to functions that describe S-shaped dissolution profiles. Overall, this work constitutes a proof of concept and provides the first steps in the development of 3D printed simple devices for the controlled release of supplements and drugs in veterinary pharmacy.
3D 打印技术用于生产兽医药房中用于口服补充剂的系统，这是一种具有吸引力但尚未开发的技术。从这个意义上说，这项工作研究了胶囊装置的设计和 3D 打印，这些装置允许尿素的控制释放，尿素经常被用作反刍动物的非蛋白氮源，但如果快速摄入则具有高度毒性。这些装置是用聚乳酸（PLA，不溶于水）和聚乙烯醇（PVA，水溶性）的组合打印的，以通过不同部分调节尿素的释放。设计和打印参数（如挤出温度、打印速度、回缩距离和喷嘴速度）的优化对于获得成功的胶囊装置至关重要。此外，溶解研究证实，所开发的设计表现出对尿素的控制释放，特别是那些具有内部隔板的设计。最后，Logistic 和 Weibull 方程是最适合描述 S 形溶解曲线的实验数据的动力学模型。总的来说，这项工作证明了概念的可行性，并为兽医药学中用于补充剂和药物控制释放的 3D 打印简单装置的开发提供了初步步骤。
