来自藿香地上部分的木脂素和苯乙醇苷类化合物。
Lignans and Phenylethanoid Glycosides from the Aerial Parts of Pogostemon cablin.
机构信息
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
出版信息
Chem Biodivers. 2022 Dec;19(12):e202200889. doi: 10.1002/cbdv.202200889. Epub 2022 Dec 5.
Two new lignans (1-2) and a new octaketide (12), together with twenty-nine known compounds (3-11, 13-32) were isolated and identified from the aerial part of Pogostemon cablin. Their chemical structures were revealed mainly through NMR and MS data. The absolute configuration of 1 and 2 was deduced by comparing its experimental CD with the calculated ECD spectra. The inhibitory activities of the isolated compounds on LPS-stimulated nitric oxide (NO) production in RAW 264.7 cells were investigated. At a concentration of 25 μM, compounds 1 and 11 showed approximately equal NO inhibitory effects to that of aminoguanidine.
从广藿香地上部分分离得到两个新的木脂素（1-2）和一个新的八聚体（12），以及 29 个已知化合物（3-11，13-32）。它们的化学结构主要通过 NMR 和 MS 数据揭示。通过比较其实验 CD 与计算 ECD 光谱，推断出 1 和 2 的绝对构型。对分离得到的化合物在 LPS 刺激 RAW 264.7 细胞中一氧化氮（NO）产生的抑制活性进行了研究。在 25 μM 浓度下，化合物 1 和 11 对 NO 的抑制作用与氨基胍相当。
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