从（Thunb.）Vahl 的地上部分中提取的具有抗氧化活性的新木脂素和苯乙醇类化合物。
New lignans and phenylethanoid with antioxidant activity from aerial parts of (Thunb.) Vahl.
机构信息
Department of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu, China.
Key Laboratory of Drug Targeting and Drug Delivery System Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China.
出版信息
Nat Prod Res. 2023 Mar;37(5):725-733. doi: 10.1080/14786419.2022.2087650. Epub 2022 Jun 24.
Two new lignans, phillyroside A() and phillyroside B(), together with three new phenylethanoid glycoside, forsythoside K(), forsythoside L() and forsythol L (), while compounds was an aglycon of forsythoside L(), were isolated from the aerial parts of (Thunb.) Vahl. Their structures were elucidated by comprehensive analyses of standard spectroscopic data (MS, IR, and NMR) and the in vitro antioxidant activity of five new compounds were evaluated in DPPH and ABTS radical scavenging experiment and ferric reducing ability of plasma (FRAP) experiment. Compounds and exhibited antioxidant activity with IC values ranging from 112.49 to 153.58 μM in DPPH experiment and 45.43 to 64.09 μM in ABTS experiment.
从（Thunb.）Vahl 的地上部分分离得到两种新的木脂素，即 phillyroside A() 和 phillyroside B()，以及三种新的苯乙醇苷，forsythoside K()、forsythoside L() 和 forsythol L ()。化合物 是 forsythoside L() 的苷元，其结构通过综合分析标准光谱数据（MS、IR 和 NMR）以及五种新化合物在 DPPH 和 ABTS 自由基清除实验以及血浆还原能力（FRAP）实验中的体外抗氧化活性来阐明。化合物 和 在 DPPH 实验中表现出抗氧化活性，IC 值范围为 112.49 至 153.58 μM，在 ABTS 实验中为 45.43 至 64.09 μM。
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