He Dongxu, Xu Chen, Xing Xiangyou
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China.
Org Lett. 2022 Nov 18;24(45):8354-8358. doi: 10.1021/acs.orglett.2c03385. Epub 2022 Nov 9.
Asymmetric transfer hydrogenation (ATH) of acyclic imines has been rarely reported by using Ru-based catalysts. In this manuscript, employing Ru-catalysts with minimal stereogenicity in combination with formic acid/triethylamine as the hydrogen donor enables a highly efficient ATH of -diphenylphosphinyl acyclic imines. These substrates that include various aryl alkyl and heteroaryl alkyl substituted imines were all compatible with this catalytic system, and the corresponding reduced amines were obtained with excellent enantiomeric excess (ee's) and yields.
使用钌基催化剂对非环状亚胺进行不对称转移氢化（ATH）的报道很少。在本论文中，使用具有最小立体异构性的钌催化剂并结合甲酸/三乙胺作为氢供体，能够实现对α-二苯基膦酰基非环状亚胺的高效不对称转移氢化。这些底物包括各种芳基烷基和杂芳基烷基取代的亚胺，均与该催化体系兼容，并以优异的对映体过量（ee值）和产率得到相应的还原胺。
