为蝙蝠单细胞研究奠定基础。

Laying the foundation for single-cell studies in bats.

作者信息

Banerjee Arinjay, Mossman Karen

机构信息

Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada; Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada; McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.

出版信息

Immunity. 2022 Nov 8;55(11):1974-1977. doi: 10.1016/j.immuni.2022.10.010.

DOI:10.1016/j.immuni.2022.10.010

PMID:36351371

Abstract

Bats serve as hosts of viruses that can cause disease in humans. In this issue of Immunity, Gamage et al. characterize the immune cell repertoire in Eonycteris spelaea bat lung tissue using single-cell transcriptomics, providing insight into the in vivo immune response to infection with a Pteropine orthoreovirus (PRV3M) and establishing a paradigm for future comparative immunology studies.

摘要

蝙蝠是可导致人类疾病的病毒宿主。在本期《免疫》杂志中，加马奇等人利用单细胞转录组学对洞穴长翼蝠的肺组织中的免疫细胞库进行了表征，深入了解了对翼手正呼肠孤病毒（PRV3M）感染的体内免疫反应，并为未来的比较免疫学研究建立了范例。