Uzamere Ivie, Wang Yinqiao, Zheng Tongzhang, Zhu Yong
Department of Environmental Health Sciences, Yale University School of Public Health, New Haven, CT, 06520, USA.
Department of Epidemiology, Brown University School of Public Health, Providence, RI, 02912, USA.
Commun Med (Lond). 2022 Nov 2;2(1):138. doi: 10.1038/s43856-022-00205-5.
A worldwide higher incidence of prostate cancer and lower incidence of testicular cancer in men of African ancestry compared to European ancestry has been observed previously. However, underlying mechanisms accounting for these observations are largely unknown.
The current study analyzed previously reported SNPs associated with either prostate cancer or testicular cancer to examine whether the risk allele frequency could help us understand the observed incidence disparities in men of African ancestry and European ancestry. Both t-test and regression analysis were performed.
Here we show that men of African ancestry are more likely to have risk alleles of prostate cancer and less likely to have risk alleles of testicular cancer compared to men of European ancestry.
Our findings suggest that genetic factors may play an important role in the racial disparities in the risk of prostate and testicular cancers.
此前观察到，与欧洲血统男性相比，非洲血统男性的前列腺癌发病率在全球范围内更高，而睾丸癌发病率更低。然而，导致这些观察结果的潜在机制在很大程度上尚不清楚。
本研究分析了先前报道的与前列腺癌或睾丸癌相关的单核苷酸多态性（SNP），以检验风险等位基因频率是否有助于我们理解在非洲血统和欧洲血统男性中观察到的发病率差异。同时进行了t检验和回归分析。
我们发现，与欧洲血统男性相比，非洲血统男性更有可能携带前列腺癌的风险等位基因，而携带睾丸癌风险等位基因的可能性更小。
我们的研究结果表明，遗传因素可能在前列腺癌和睾丸癌风险的种族差异中起重要作用。
