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一种使用改性β-环糊精作为催化剂一锅合成 3,4-二取代异噁唑-5(4H)-酮的绿色方法。

A green protocol for the one-pot synthesis of 3,4-disubstituted isoxazole-5(4H)-ones using modified β-cyclodextrin as a catalyst.

机构信息

Research Laboratory of Green Organic Synthesis & Polymers, Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114, Tehran, Iran.

Peptide Chemistry Research Institute, K.N Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran.

出版信息

Sci Rep. 2022 Nov 9;12(1):19106. doi: 10.1038/s41598-022-23814-5.

DOI:10.1038/s41598-022-23814-5
PMID:36352247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9646907/
Abstract

This manuscript reports an impressive and facile strategy for synthesizing isoxazole derivatives using immobilized Cu (I) in metformin-functionalized β-cyclodextrin as a catalyst. The architecture of this catalyst was characterized by different analytical techniques such as Fourier transform infrared spectroscopy, Thermogravimetric analysis, X-ray diffraction, Field emission scanning electron microscopy, and Energy-dispersive X-ray spectroscopy. The catalyst showed remarkable reusability even after 7 consecutive runs.

摘要

这篇手稿报道了一种使用固定化 Cu（I）在二甲双胍功能化β-环糊精作为催化剂合成异恶唑衍生物的令人印象深刻且简便的策略。该催化剂的结构通过不同的分析技术进行了表征，例如傅里叶变换红外光谱、热重分析、X 射线衍射、场发射扫描电子显微镜和能谱分析。该催化剂甚至在经过 7 次连续运行后仍表现出出色的可重复使用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/e50bbbb50ad1/41598_2022_23814_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/c673969ef92a/41598_2022_23814_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/0374a487ffb2/41598_2022_23814_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/634799c73ff8/41598_2022_23814_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/6ec569faaf44/41598_2022_23814_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/9bd8428291a0/41598_2022_23814_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/2eda7fcb5137/41598_2022_23814_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/fef171dab066/41598_2022_23814_Sch3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/8d7c4e594f8f/41598_2022_23814_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/e50bbbb50ad1/41598_2022_23814_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/b86c68faeb63/41598_2022_23814_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/c673969ef92a/41598_2022_23814_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/0374a487ffb2/41598_2022_23814_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/634799c73ff8/41598_2022_23814_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/6ec569faaf44/41598_2022_23814_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/9bd8428291a0/41598_2022_23814_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/2eda7fcb5137/41598_2022_23814_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/fef171dab066/41598_2022_23814_Sch3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/8d7c4e594f8f/41598_2022_23814_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e1/9646907/e50bbbb50ad1/41598_2022_23814_Fig7_HTML.jpg

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