Mohassel Yazdi Nazanin, Naimi-Jamal Mohammad Reza
Research Laboratory of Green Organic Synthesis & Polymers, Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114, Tehran, Iran.
Sci Rep. 2024 May 16;14(1):11189. doi: 10.1038/s41598-024-61803-y.
The nanoporous compound SBA-15 was functionalized using (3-aminopropyl)trimethoxysilane (APTES). Then the obtained product was modified with ellagic acid (ELA), a bioactive polyphenolic compound. The structure of the prepared nanoporous composition SBA-15@ELA was extensively characterized and confirmed by various techniques, such as Fourier-transform infrared (FT-IR) spectroscopy, Energy dispersive X-ray (EDX) elemental analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM) and N adsorption-desorption isotherms (BET). The novel, recoverable, heterogenous SBA-15@ELA nanoporous compound was used to investigate its catalytic effect in the synthesis of 4-oxo-quinazoline derivatives (19 examples) with high yields (78-96%), as an important class of nitrogen-containing heterocyclic compounds. The use of an inexpensive mesoporous catalyst with a high surface area, along with easy recovery by simple filtration are among the advantages of this catalysis research work. The catalyst has been used in at least 6 consecutive runs without a significant loss of its activity.
采用（3-氨丙基）三甲氧基硅烷（APTES）对纳米多孔化合物SBA-15进行功能化处理。然后用生物活性多酚化合物鞣花酸（ELA）对所得产物进行改性。通过傅里叶变换红外（FT-IR）光谱、能量色散X射线（EDX）元素分析、扫描电子显微镜（SEM）、热重分析（TGA）、X射线衍射（XRD）、透射电子显微镜（TEM）和N吸附-脱附等温线（BET）等多种技术对制备的纳米多孔组合物SBA-15@ELA的结构进行了广泛表征和确认。这种新型的、可回收的、非均相的SBA-15@ELA纳米多孔化合物用于研究其在合成4-氧代喹唑啉衍生物（19个实例）中的催化作用，该类衍生物产率高（78-96%），是一类重要的含氮杂环化合物。使用具有高表面积的廉价介孔催化剂以及通过简单过滤易于回收是这项催化研究工作的优点之一。该催化剂已连续至少使用6次，其活性没有明显损失。
