Xia Tong, Chen Liwei, Fei Zhe, Liu Xinyue, Dai Jin, Hinkle Stefanie N, Zhu Yeyi, Wu Jing, Weir Natalie L, Tsai Michael Y, Zhang Cuilin
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States.
Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States.
Front Nutr. 2022 Oct 24;9:983418. doi: 10.3389/fnut.2022.983418. eCollection 2022.
Physical activity (PA) during pregnancy influences women and offspring's health fatty acids metabolism. However, studies on associations of PA with plasma monounsaturated fatty acids (MUFAs) across pregnancy are sparse. Thus, our study aimed to examine associations of PA with individual plasma phospholipid MUFAs throughout pregnancy in a prospective and longitudinal study in the United States (US).
The study included 318 pregnant women from the National Institute of Child Health and Human Development Fetal Growth Studies-Singletons cohort. PA was measured four times: PA reported at 10-14 gestational weeks (GWs) representing PA in the past year, and at 15-26 GWs, 23-31 GWs, and 33-39 GWs representing PA since the last visit. Plasma phospholipid MUFAs were measured at the same four visits as the measurement of PA. Associations between moderate-to-vigorous PA (MVPA) and the total MUFAs and seven individual plasma phospholipid MUFAs (i.e., palmitoleic acid, 18:1n6-9 , 18:1n6c, vaccenic acid, oleic acid, eicosenoic acid, and nervonic acid) were assessed at each visit using multivariable linear regression models adjusting for confounders.
MVPA (hours/week) reported at 15-26 GWs representing MVPA since the last visit was positively associated with total MUFAs (% of total fatty acids) [adjusted β10 (standard error (SE)10) = 10.41 (3.19), = 0.001] at 15-26 GWs. For individual MUFAs, MVPA reported at 15-26 GWs representing MVPA since the last visit was positively associated with oleic acid [adjusted β10 (SE10) = 8.56 (2.65), = 0.001] and eicosenoic acid [adjusted β10 (SE10) = 0.55 (0.20), = 0.01] at 15-26 GWs. MVPA reported at 23-31 GWs representing MVPA since the last visit was positively associated with palmitoleic acid [adjusted β10 (SE10) = 2.24 (0.64), = 0.001] at 23-31 GWs. MVPA reported at 10-14 GWs and 33-39 GWs was not associated with total or individual MUFAs.
We found novel positive associations of MVPA with individual MUFAs, such as oleic acid, eicosenoic acid, and palmitoleic acid, during middle-to-late pregnancy. These findings suggest that MVPA represents a potentially modifiable factor for plasma individual MUFA levels during pregnancy.
孕期身体活动（PA）会影响女性及后代的健康和脂肪酸代谢。然而，关于孕期PA与血浆单不饱和脂肪酸（MUFA）之间关联的研究较少。因此，我们的研究旨在通过在美国进行的一项前瞻性纵向研究，探讨孕期PA与个体血浆磷脂MUFA之间的关联。
该研究纳入了来自美国国立儿童健康与人类发展研究所单胎胎儿生长研究队列的318名孕妇。PA测量了四次：妊娠10 - 14周（GW）时报告的PA代表过去一年的PA，以及在15 - 26 GW、23 - 31 GW和33 - 39 GW时报告的PA代表自上次就诊以来的PA。血浆磷脂MUFA在与PA测量相同的四次就诊时进行测量。使用调整了混杂因素的多变量线性回归模型，在每次就诊时评估中度至剧烈身体活动（MVPA）与总MUFA以及七种个体血浆磷脂MUFA（即棕榈油酸、18:1n6 - 9、18:1n6c、反式vaccenic酸、油酸、二十碳烯酸和神经酸）之间的关联。
在15 - 26 GW时报告的代表自上次就诊以来的MVPA（小时/周）与15 - 26 GW时的总MUFA（占总脂肪酸的百分比）呈正相关[调整后的β10（标准误（SE）10） = 10.41（3.19），P = 0.001]。对于个体MUFA，在15 - 26 GW时报告的代表自上次就诊以来的MVPA与15 - 26 GW时的油酸[调整后的β10（SE10） = 8.56（2.65），P = 0.001]和二十碳烯酸[调整后的β10（SE10） = 0.55（0.20），P = 0.01]呈正相关。在23 - 31 GW时报告的代表自上次就诊以来的MVPA与23 - 31 GW时的棕榈油酸[调整后的β10（SE10） = 2.24（0.64），P = 0.001]呈正相关。在10 - 14 GW和33 - 39 GW时报告的MVPA与总MUFA或个体MUFA均无关联。
我们发现孕期中晚期MVPA与个体MUFA（如油酸、二十碳烯酸和棕榈油酸）之间存在新的正相关。这些发现表明，MVPA可能是孕期血浆个体MUFA水平的一个潜在可调节因素。
