Chakraborty Debabrata, Bhaumik Sanjay, Agarwal Sushil, Sen Sagar, Majumder Saptarshi
Department of Neurology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India.
Department of Respiratory Medicine, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India.
J Family Med Prim Care. 2022 Aug;11(8):4818-4820. doi: 10.4103/jfmpc.jfmpc_278_22. Epub 2022 Aug 30.
We often face situations when the exact etiological diagnosis of meningitis is difficult. The reason behind this is that many pathogens have similar clinical, radiological, and laboratory pictures. The low yield of the pathogen in cerebrospinal fluid (CSF), non-availability of detail tests in all corners of the world, delay in availability of reliable results (like cultures), and difficulty in performing confirmatory tests like brain biopsy (in inconclusive cases) make the job of a clinician challenging. We report here a case where a late diagnosis of a disease owing to inconclusive results leads to dissemination. The complications following the introduction of the treatment based on presumption lead to further difficulty. We remained inclined to our diagnosis based on clinical judgement, acknowledged and managed the inflammatory changes secondary to the infection, and finally won the long battle. So, sometimes we need to make decisions based on clinical grounds. We need to depend on the fact that uncommon presentations of common diseases are commoner than a common presentation of uncommon diseases.
我们常常面临难以对脑膜炎进行确切病因诊断的情况。其背后的原因是许多病原体具有相似的临床、影像学和实验室表现。脑脊液(CSF)中病原体检出率低、世界各地并非都能进行详细检测、可靠结果(如培养结果)获取延迟以及在不确定病例中进行脑活检等确诊检测存在困难,这些都使得临床医生的工作具有挑战性。我们在此报告一例因结果不确定导致疾病诊断延迟并扩散的病例。基于推测进行治疗后出现的并发症导致了进一步的困难。我们基于临床判断坚持我们的诊断,认识并处理了感染继发的炎症变化,最终赢得了这场持久战。所以,有时我们需要基于临床依据做出决策。我们需要依据这样一个事实,即常见疾病的不常见表现比罕见疾病的常见表现更为常见。