认知未受损的老年人的脑血流量、tau蛋白成像与记忆关联

Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults.

作者信息

Weigand Alexandra J, Hamlin Abbey M, Breton Jordana, Clark Alexandra L

机构信息

San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, United States.

Department of Psychology, College of Liberal Arts, University of Texas at Austin, 108 East Dean Keeton, SEA 3.234, Austin, TX 78712, United States.

出版信息

Cereb Circ Cogn Behav. 2022 Oct 27;3:100153. doi: 10.1016/j.cccb.2022.100153. eCollection 2022.

DOI:10.1016/j.cccb.2022.100153

PMID:36353072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9637859/

Abstract

OBJECTIVE

Cerebral blood flow (CBF) has been independently linked to cognitive impairment and traditional Alzheimer's disease (AD) pathology (e.g., amyloid-beta [Aβ], tau) in older adults. However, less is known about the possible interactive effects of CBF, Aβ, and tau on memory performance. The present study examined whether CBF moderates the effect of Aβ and tau on objective and subjective memory within cognitively unimpaired (CU) older adults.

METHODS

Participants included 54 predominately white CU older adults from the Alzheimer's Disease Neuroimaging Initiative. Multiple linear regression models examined meta-temporal CBF associations with (1) meta-temporal tau PET adjusting for cortical Aβ PET and (2) and cortical Aβ PET adjusting for tau PET. The CBF and tau meta region was an average of 5 distinct temporal lobe regions. CBF interactions with Aβ or tau PET on memory performance were also examined. Covariates for all models included age, sex, education, pulse pressure, APOE-ε4 positivity, and imaging acquisition date differences.

RESULTS

CBF was significantly negatively associated with tau PET ( = -2.16,  = .04) but not Aβ PET ( = 0.98,  = .33). Results revealed a CBF by tau PET interaction such that there was a stronger effect of tau PET on objective ( = 2.51,  = .02) and subjective ( = -2.67,  = .01) memory outcomes among individuals with lower levels of CBF.

CONCLUSIONS

Cerebrovascular and tau pathologies may interact to influence cognitive performance. This study highlights the need for future vascular risk interventions, which could offer a scalable and cost-effective method for AD prevention.

摘要

目的

在老年人中，脑血流量（CBF）已被独立地与认知障碍和传统阿尔茨海默病（AD）病理（如β淀粉样蛋白[Aβ]、tau蛋白）联系起来。然而，关于CBF、Aβ和tau蛋白对记忆表现可能的交互作用，人们了解得较少。本研究考察了CBF是否会调节Aβ和tau蛋白对认知未受损（CU）老年人客观和主观记忆的影响。

方法

参与者包括来自阿尔茨海默病神经影像学计划的54名以白人为主的CU老年人。多个线性回归模型检验了颞叶CBF与（1）经皮质Aβ正电子发射断层扫描（PET）校正后的颞叶tau蛋白PET以及（2）经tau蛋白PET校正后的皮质Aβ PET之间的关联。CBF和tau蛋白的元区域是5个不同颞叶区域的平均值。还考察了CBF与Aβ或tau蛋白PET对记忆表现的交互作用。所有模型的协变量包括年龄、性别、教育程度、脉压、APOE-ε4阳性以及成像采集日期差异。

结果

CBF与tau蛋白PET显著负相关（β = -2.16，p = .04），但与Aβ PET无显著相关性（β = 0.98，p = .33）。结果显示存在CBF与tau蛋白PET的交互作用，即CBF水平较低的个体中，tau蛋白PET对客观（β = 2.51，p = .02）和主观（β = -2.67，p = .01）记忆结果的影响更强。