Pływaczewska-Jakubowska Magdalena, Chudzik Michał, Babicki Mateusz, Kapusta Joanna, Jankowski Piotr
Department of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Family Medicine, Wroclaw Medical University, Wroclaw, Poland.
Front Med (Lausanne). 2022 Oct 24;9:1036556. doi: 10.3389/fmed.2022.1036556. eCollection 2022.
The coronavirus disease (COVID) 2019 pandemic remains a great challenge for the healthcare system. The widely reported prolonged signs and symptoms resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (Long-COVID) require medical care. The aim of the study was to assess factors, including lifestyle variables, related to the course of COVID-19 infection and to assess their impact on prolonged symptoms in non-hospitalized patients with COVID-19.
A total of 1,847 (637 men and 1,210 women) non-hospitalized participants of the STOP-COVID registry of the PoLoCOV-Study who, following the COVID-19, underwent check-up examinations at the cardiology outpatient clinic were included in the analysis.
The study participants (median age 51 [41-62] years) were evaluated at 13.4 (8.4-23.6) weeks following the diagnosis of COVID-19. Female sex (odds ratio [OR] 1.46 [95% CI 1.19-1.78]), body mass index (BMI; per 1 kg/m: 1.02 [1.00-1.04]), hypertension (1.39 [1.07-1.81]), asthma (1.55 [1.06-2.27]), stress or overworking (1.54 [1.25-1.90]), and nightshift work (1.51 [1.06-2.14]) were independently related to the severity of symptoms during acute phase of the COVID-19 infection. The Long-COVID syndrome was independently related to the female sex (1.42 [1.13-1.79]), history of myocardial infarction (2.57 [1.04-6.32]), asthma (1.56 [1.01-2.41]), and severe course of the acute phase of the COVID-19 infection (2.27 [1.82-2.83]).
Female sex, BMI, asthma, hypertension, nightshifts, and stress or overworking are significantly related to the severity of the acute phase of the COVID-19 infection, while female sex, asthma, history of myocardial infarction, and the severity of symptoms in the acute phase of COVID-19 are the predictors of Long-COVID in non-hospitalized patients. We did not find an independent relation between Long-COVID and the studied lifestyle factors.
2019年冠状病毒病（COVID）大流行仍然是医疗系统面临的巨大挑战。严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染导致的广泛报道的长期症状（长期新冠）需要医疗护理。本研究的目的是评估与COVID-19感染病程相关的因素，包括生活方式变量，并评估它们对非住院COVID-19患者长期症状的影响。
共有1847名（637名男性和1210名女性）来自PoLoCOV研究的STOP-COVID登记处的非住院参与者纳入分析，这些参与者在感染COVID-19后在心脏病门诊接受了检查。
研究参与者（中位年龄51[41-62]岁）在COVID-19诊断后的13.4（8.4-23.6）周接受评估。女性（优势比[OR]1.46[95%置信区间1.19-1.78]）、体重指数（BMI；每1kg/m²：1.02[1.00-1.04]）、高血压（1.39[1.07-1.81]）、哮喘（1.55[1.06-2.27]）、压力或过度劳累（1.54[1.25-1.90]）以及夜班工作（1.51[1.06-2.14]）与COVID-19感染急性期症状的严重程度独立相关。长期新冠综合征与女性（1.42[1.13-1.79]）、心肌梗死病史（2.57[1.04-6.32]）、哮喘（1.56[1.01-2.41]）以及COVID-19感染急性期的严重病程（2.27[1.82-2.83]）独立相关。
女性、BMI、哮喘、高血压、夜班工作以及压力或过度劳累与COVID-19感染急性期的严重程度显著相关，而女性、哮喘、心肌梗死病史以及COVID-19急性期症状的严重程度是非住院患者长期新冠的预测因素。我们未发现长期新冠与所研究的生活方式因素之间存在独立关系。
