Diciolla A, Gianoni M, Fleury M, Szturz P, Demartines N, Peters S, Duran R, Desseauve D, Panchaud Monnat A, Fasquelle F, Digklia A
Département d'Oncologie, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Front Oncol. 2022 Oct 24;12:1006387. doi: 10.3389/fonc.2022.1006387. eCollection 2022.
Gallbladder cancer (GBC) represents the most common biliary tract cancer. Prognosis remains poor with 5-year overall survival rates less than 5% in advanced stages. GBCs are diagnosed more frequently in women, supposedly due to endocrine factors.
A 35-year-old woman, diagnosed with a non-metastatic GBC in the 22nd week of gestation, underwent a complete surgical resection 5 weeks later. Adjuvant gemcitabine was administered without complications, temporarily discontinued in the 32nd week to allow childbirth. The patient was disease-free for more than 3 years with ongoing remission at the last visit in July 2022. During the follow-up period, the child had no developmental, cognitive, or other health issues.
Malignant tumors occur in about 0.1% of pregnant women, many are treated with chemotherapy. In oncology, the need to deliver optimal treatment in these patients represents a major concern. Both surgery and adjuvant chemotherapy of locally advanced GBC can be performed safely, with certain considerations, in the second trimester of pregnancy.
胆囊癌（GBC）是最常见的胆道癌。晚期患者的5年总生存率低于5%，预后仍然很差。GBC在女性中更常被诊断出来，推测是由于内分泌因素。
一名35岁女性，在妊娠第22周被诊断为非转移性GBC，5周后接受了完整的手术切除。给予辅助吉西他滨治疗，无并发症，在第32周暂时停药以允许分娩。患者无病生存超过3年，在2022年7月的最后一次随访中仍处于持续缓解状态。在随访期间，孩子没有发育、认知或其他健康问题。
约0.1%的孕妇会发生恶性肿瘤，许多患者接受化疗。在肿瘤学中，为这些患者提供最佳治疗的必要性是一个主要关注点。在妊娠中期，在进行某些考虑的情况下，局部晚期GBC的手术和辅助化疗都可以安全地进行。
