沙特女性2型糖尿病患者血浆Gremlin 1水平与身体肥胖及血糖控制的关系

Relationship of Plasma Gremlin 1 Levels with Body Adiposity and Glycemic Control in Saudi Female Type 2 Diabetes Patients.

作者信息

Al-Regaiey Khalid A, Habib Syed Shahid, Alshamasi Ahmed R, Alnuwaybit Abdullah F, Alwhaibi Bader A, Alsulais Naif M, Alothman Abdullah I, Alomar Faisal M, Iqbal Muhammad

机构信息

Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Diabetes Metab Syndr Obes. 2022 Nov 3;15:3429-3436. doi: 10.2147/DMSO.S372146. eCollection 2022.

DOI:10.2147/DMSO.S372146

PMID:36353668

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9639591/

Abstract

OBJECTIVE

Gremlin 1 is a novel adipokine that plays an important role in obesity and type 2 diabetes mellitus (T2DM). In the current study, we aimed to evaluate plasma levels of Gremlin 1 in diabetic and non-diabetic Saudi adult females and its correlation with body composition, glycemic control and lipid profile.

METHODS

A case-control study was conducted among 41 T2DM and 31 non-diabetic adult age matched females (controls). All patients underwent body composition by bioelectrical impedance analysis, with a commercially available body analyzer. Fasting venous samples were analyzed for glycemic markers and lipids, while plasma Gremlin 1 was measured by ELISA. The results were compared between the two groups and correlated with other anthropometric and adiposity parameters.

RESULTS

Gremlin 1 levels were elevated in T2DM patients (345 ± 26 ng/mL) when compared to control subjects (272 ± 16 ng/mL, p < 0.05). Diabetic patients having poor glycemic control had significantly higher Gremlin 1 levels (382 ± 34 ng/mL) compared to patients with good glycemic control (291 ± 37 ng/mL, p < 0.05). Pearson correlation analysis revealed a positive correlation of Gremlin 1 with fat mass (r = 0.246, p = 0.012), HbA1C (r = 0.262, p = 0.008) and HOMA-IR index (r = 0.321, p = 0.001).

CONCLUSION

Our study demonstrates an important role of Gremlin 1 in glycemic control and body adiposity in the pathophysiology of obesity and T2DM. Gremlin 1 may emerge as a promising biomarker and therapeutic target in obesity and T2DM.

摘要

目的

Gremlin 1是一种新型脂肪因子，在肥胖症和2型糖尿病（T2DM）中发挥重要作用。在本研究中，我们旨在评估沙特成年糖尿病和非糖尿病女性的血浆Gremlin 1水平及其与身体成分、血糖控制和血脂谱的相关性。

方法

对41例T2DM成年女性和31例年龄匹配的非糖尿病成年女性（对照组）进行病例对照研究。所有患者均使用市售人体分析仪通过生物电阻抗分析进行身体成分检测。采集空腹静脉血样分析血糖指标和血脂，同时采用酶联免疫吸附测定法（ELISA）检测血浆Gremlin 1。比较两组结果，并与其他人体测量和肥胖参数进行相关性分析。

结果

与对照组（272±16 ng/mL，p<0.05）相比，T2DM患者的Gremlin 1水平升高（345±26 ng/mL）。血糖控制差的糖尿病患者的Gremlin 1水平（382±34 ng/mL）显著高于血糖控制良好的患者（291±37 ng/mL，p<0.05）。Pearson相关性分析显示，Gremlin 1与脂肪量（r = 0.246，p = 0.012）、糖化血红蛋白（HbA1C，r = 0.262，p = 0.008）和胰岛素抵抗指数（HOMA-IR，r = 0.321，p = 0.001）呈正相关。