Al Qarni Ali Ahmed, Joatar Faris Elbahi, Das Nagalla, Awad Mohamed, Eltayeb Mona, Al-Zubair Ahmed Gasim, Ali Muhalab E, Al Masaud Abdulaziz, Shire Abdirashid M, Gumaa Khalid, Giha Hayder A
Department of Internal Medicine and Clinical Biochemistry Laboratory, King Abdulaziz Hospital, National Guard Health Affairs, Al-Ahsa, Saudi Arabia.
Clinical Biochemistry Laboratory, Salmaniya Medical Complex, Manama, Bahrain.
Endocrinol Metab (Seoul). 2017 Jun;32(2):230-240. doi: 10.3803/EnM.2017.32.2.230. Epub 2017 May 29.
Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM.
Patients with T2DM (n=107, cases) and non-diabetic apparently healthy subjects (n=101, controls) from Saudi Arabia were included in this study. The biochemical profiles and plasma insulin levels of all subjects were analyzed, and IR was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Active ghrelin levels in plasma were measured using the radioimmunoassay technique.
Only 46.7% (50 of 107) of the T2DM subjects had IR, including 26% (28 of 107) with severe IR (HOMA-IR ≥5), while 5.9% (six of 101) of the controls had moderate IR (3 ≤HOMA-IR <5). HOMA-IR values were not associated with age, disease duration, or gender. Importantly, T2DM itself and the co-occurrence of IR with T2DM were significantly associated with low plasma ghrelin levels. However, ghrelin levels were inversely correlated with the HOMA-IR index, body weight, and fasting plasma insulin levels, mainly in the control subjects, which was indicative of the breakdown of metabolic homeostasis in T2DM.
The prevalence of IR was relatively low, and IR may be inversely associated with plasma ghrelin levels among Saudi patients with T2DM.
尽管胰岛素抵抗（IR）的确切机制尚未明确，但IR是2型糖尿病（T2DM）的标志性特征。本研究旨在探讨沙特T2DM患者血浆胃饥饿素水平与IR之间的关系。
本研究纳入了来自沙特阿拉伯的T2DM患者（n = 107，病例组）和非糖尿病的明显健康受试者（n = 101，对照组）。分析了所有受试者的生化指标和血浆胰岛素水平，并使用胰岛素抵抗稳态模型评估（HOMA-IR）指数来估计IR。采用放射免疫测定技术测量血浆中活性胃饥饿素水平。
仅46.7%（107例中的50例）的T2DM受试者存在IR，其中26%（107例中的28例）患有严重IR（HOMA-IR≥5），而对照组中有5.9%（101例中的6例）患有中度IR（3≤HOMA-IR<5）。HOMA-IR值与年龄、病程或性别无关。重要的是，T2DM本身以及IR与T2DM的同时存在与低血浆胃饥饿素水平显著相关。然而，胃饥饿素水平与HOMA-IR指数、体重和空腹血浆胰岛素水平呈负相关，主要在对照组中如此，这表明T2DM中代谢稳态的破坏。
IR的患病率相对较低，并且在沙特T2DM患者中，IR可能与血浆胃饥饿素水平呈负相关。
