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一名年轻女性患者继发于[此处原文缺失内容]的原发性脑膜炎球菌性心包炎病例报告。

A case report of primary meningococcal pericarditis secondary to in a young female patient.

作者信息

Green Matthew, Harrison Peter, Sengupta Anshuman, Schlosshan Dominik

机构信息

Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Great George Street, Leeds LS1 3EX, United Kingdom.

出版信息

IDCases. 2022 Nov 1;30:e01634. doi: 10.1016/j.idcr.2022.e01634. eCollection 2022.

Abstract

Pericarditis is responsible for approximately 5 % of emergency admissions due to chest pain. Pericarditis secondary to Neisseria meningitidis (meningococci) was originally reported in 1918, and remains a rare diagnosis. We report a case of primary meningococcal pericarditis presenting with non-specific symptoms, illustrating the importance of considering rarer causes of pericardial effusion. A previously fit and well 23-year-old female presented to her local hospital with a 2-day history of feeling generally unwell with myalgia and fevers and was initially discharged. Four days following discharge the patient re-presented with worsening symptoms. A Computed Tomography Pulmonary Angiogram (CTPA) demonstrated a large pericardial effusion with subsequent bedside echocardiogram confirming a global pericardial effusion of up to 3 cm. This required drainage, with blood cultures and pericardial fluid showing polymerase chain reaction positivity for Neisseria meningitidis, serogroup B. Our report describes a rare case of Primary Meningococcal Pericarditis secondary to serotype B meningococcal infection. The European Society of Cardiology propose criteria that warrant hospital admission and an aetiology search for certain patients with pericardial disease. These criteria provide a useful framework to help select those minority of patients in whom a more serious underlying cause is present. Blood cultures provide vital information to allow us to complete a thorough aetiological search and empirical antibiotics can cloud the clinical picture, making it harder to identify causative organisms. To aid the early administration of appropriate therapy, it may be pertinent to recommend a low threshold for taking blood cultures in patients with pyrexia and pericarditis or pericardial effusion.

摘要

心包炎约占因胸痛而急诊入院病例的5%。继发于脑膜炎奈瑟菌(脑膜炎球菌)的心包炎最初于1918年被报道,至今仍属罕见诊断。我们报告一例以非特异性症状表现的原发性脑膜炎球菌心包炎病例,以说明考虑心包积液罕见病因的重要性。一名此前健康的23岁女性因全身不适、肌痛和发热2天就诊于当地医院,最初被出院。出院后四天,患者症状加重再次就诊。计算机断层扫描肺动脉造影(CTPA)显示大量心包积液,随后床边超声心动图证实心包积液最大深度达3厘米。这需要进行引流,血培养和心包积液聚合酶链反应检测显示B群脑膜炎奈瑟菌呈阳性。我们的报告描述了一例罕见的继发于B型血清型脑膜炎球菌感染的原发性脑膜炎球菌心包炎病例。欧洲心脏病学会提出了某些心包疾病患者需要住院治疗并进行病因排查的标准。这些标准为帮助筛选出存在更严重潜在病因的少数患者提供了有用的框架。血培养提供了至关重要的信息,使我们能够完成全面的病因排查,而经验性使用抗生素可能会模糊临床症状,更难识别致病微生物。为有助于早期给予适当治疗,对于发热且伴有心包炎或心包积液的患者,建议采用较低阈值进行血培养检查可能是恰当的。

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本文引用的文献

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