配体龙主要双羟化长期代谢标志物的结构修饰和化学合成。
Structure revision and chemical synthesis of ligandrol's main bishydroxylated long-term metabolic marker.
机构信息
National Centre for Scientific Research "DEMOKRITOS", Institute of Nanoscience and Nanotechnology, "Natural Products Synthesis and Bioorganic Chemistry" Laboratory, P.O. Box 60037, GR 153 10 Aghia Paraskevi, Athens, Greece.
National Centre for Scientific Research "DEMOKRITOS", Institute of Biosciences & Applications, Doping Control Laboratory of Athens, Neratziotissis & Amaryssias Artemidos Str, GR 151 23 Athens, Greece.
出版信息
Org Biomol Chem. 2022 Nov 30;20(46):9112-9116. doi: 10.1039/d2ob01907h.
Although the main bishydroxylated long-term metabolite of the WADA-banned anabolic agent ligandrol (LGD-4033) is an important metabolic marker, it is not readily available in sufficient quantities to facilitate the development and validation of related analytical protocols or sensors. A chemically more robust structure was postulated as an alternative to the one previously established. The NMR spectra of the synthesized material and its LC-HRMS comparison with a relevant metabolic sample support the proposed structural revision.
尽管世界反兴奋剂机构禁用的同化代谢剂 LGD-4033 的主要双羟化长期代谢物是一种重要的代谢标志物，但它的数量并不足以用于相关分析协议或传感器的开发和验证。因此，人们推测可以使用一种化学性质更稳定的结构来替代之前建立的结构。合成材料的 NMR 谱及其与相关代谢物样品的 LC-HRMS 比较支持所提出的结构修订。
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