Martins Mariana, Mascarenhas Paulo, Evangelista José Grillo, Barahona Isabel, Tavares Vitor
Instituto Universitário Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Almada, Portugal.
Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Almada, Portugal.
Dent J (Basel). 2022 Oct 31;10(11):205. doi: 10.3390/dj10110205.
Scientific evidence regarding the incidence of dental caries in Down syndrome (DS) patients is limited and sometimes presents divergent opinions among authors, making it difficult to reach definitive conclusions. We aimed to evaluate the caries incidence in the DS pediatric population and compare it against healthy controls. The search was performed using 4 universal databases: Cochrane, B-on, Biomed, and PubMed. The selected articles were synthesized and subsequently evaluated according to an adaptation of the Quality Assessment Checklist for Prevalence Studies risk of bias tool, and analysis charts were performed by the Risk of Bias visualization tool (ROBVIS). Statistics and graphs were performed by Open Meta Analyst and JASP software. The confounding effect on caries incidence of the following factors was evaluated through meta-regression: age, Male/Female (M/F) ratio, DMFT, dmft, and study geographic location. Overall, the incidence of caries in the DS population was 49.9%, whereas in the control population was 63.4%. The M/F ratio, DMFT, and dmft significantly affected the incidence of DS individuals (p-value < 0.05). The evidence regarding the lower pooled incidence of caries in individuals with DS regarding controls is limited by the few scientific reports available and cross-section designs. Therefore, further studies are needed to confirm these results.
关于唐氏综合征（DS）患者龋齿发病率的科学证据有限，而且作者之间有时存在不同意见，难以得出明确结论。我们旨在评估DS儿童群体中的龋齿发病率，并与健康对照组进行比较。检索使用了4个通用数据库：Cochrane、B-on、Biomed和PubMed。对所选文章进行综合分析，随后根据患病率研究偏倚风险工具的质量评估清单改编版进行评估，并通过偏倚风险可视化工具（ROBVIS）制作分析图表。统计和图表由Open Meta Analyst和JASP软件完成。通过meta回归评估以下因素对龋齿发病率的混杂效应：年龄、男/女（M/F）比例、恒牙龋失补牙数（DMFT）、乳牙龋失补牙数（dmft）和研究地理位置。总体而言，DS人群的龋齿发病率为49.9%，而对照组人群为63.4%。M/F比例、DMFT和dmft对DS个体的发病率有显著影响（p值<0.05）。关于DS个体相对于对照组龋齿合并发病率较低的证据，因现有科学报告数量较少以及横断面设计而受到限制。因此，需要进一步研究来证实这些结果。
