Department of Ophthalmology, Hospital of Ludwigshafen, Akademisches Lehrkrankenhaus der Johannes-Gutenberg-Universität Mainz und der Medizinischen Fakultät Mannheim der Universität Heidelberg, Ludwigshafen am Rhein, Germany.
Department of Ophthalmology, University of Lübeck, Lübeck, Germany.
Neurosignals. 2022 Nov 11;30(S1):39-58. doi: 10.33594/000000585.
Retinoblastoma (RB) management has evolved over the last three decades. Goals of modern RB treatment are first to protect life and prevent metastatic disease, then preservation of the globe and useful vision. With modern treatment protocols and early disease detection success rates can reach up to 100% of disease-free-globe and eye preservation. Treatment of advanced cases remains complex, requiring aggressive chemotherapy or/and external beam radiation. Treatment protocols are extremely diverse and dependent on local resources thus success rates are variable. Here we review narratively current treatment protocols and failure rates based on a PubMed search using keywords of retinoblastoma, retinoblastoma seed, retinoblastoma treatment, enucleation.
视网膜母细胞瘤（RB）的管理在过去三十年中已经发生了变化。现代 RB 治疗的目标首先是保护生命，预防转移性疾病，然后是保护眼球和有用的视力。通过现代治疗方案和早期疾病检测，无病眼球和眼部保存的成功率可达 100%。晚期病例的治疗仍然很复杂，需要积极的化疗或/和外照射治疗。治疗方案极其多样化，取决于当地资源，因此成功率也各不相同。在这里，我们根据使用“视网膜母细胞瘤、RB 种子、RB 治疗、眼球摘除”等关键词在 PubMed 上进行的搜索，以叙述的方式回顾当前的治疗方案和失败率。
