Department of Radiation Oncology, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
J Appl Clin Med Phys. 2023 Jan;24(1):e13842. doi: 10.1002/acm2.13842. Epub 2022 Nov 10.
Total-body irradiation (TBI) has been used as a part of the conditioning regimen for patients undergoing hematopoietic stem cell transplantation for certain nonmalignant conditions such as sickle cell disease. Although effective, TBI can cause lasting side effects for pediatric patients. One of these potential side effects includes oligospermia or even permanent azoospermia. Although many investigators have studied ways to shield the testicles during the TBI for nonmalignant conditions, there is no set standard. We describe the technical aspects of effective techniques to shield the testicles of male pediatric patients undergoing TBI. We verified that our techniques reduced the testicular dose by approximately 80%-85% of the TBI prescription dose in four male pediatric patients, keeping the dose well below the documented doses that can cause permanent infertility and hypogonadism.
全身照射（TBI）已被用作接受造血干细胞移植的某些非恶性疾病患者的预处理方案的一部分，例如镰状细胞病。虽然有效，但 TBI 会对儿科患者造成持久的副作用。其中一种潜在的副作用包括少精症，甚至是永久性无精症。尽管许多研究人员已经研究了在非恶性疾病的 TBI 期间保护睾丸的方法，但目前尚无标准方法。我们描述了对接受 TBI 的男性儿科患者的睾丸进行有效屏蔽的技术方面。我们验证了我们的技术可以将四个男性儿科患者的睾丸剂量降低到 TBI 处方剂量的 80％-85％左右，使剂量远远低于可导致永久性不育和性腺功能减退的记录剂量。
