辐射对男性生育力的影响。
Radiation effects on male fertility.
机构信息
Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
出版信息
Andrology. 2019 Jan;7(1):2-7. doi: 10.1111/andr.12562. Epub 2018 Nov 9.
BACKGROUND
Spermatogenesis is a process of dynamic cell differentiation. Ionizing radiation impairs spermatogenesis, and spermatogonia are more radiosensitive than spermatocytes or spermatids. Consistent with this assumption and due to improvement in tumor curability, nowadays, fertility preservation represents a public health need.
OBJECTIVES
To discuss radiotherapy-induced risk to male fertility and raise oncologic awareness of male fertility in daily clinical practice.
MATERIALS AND METHODS
PubMed and Clinicaltrials.gov databases were searched for papers in English.
RESULTS
We provide an overview of clinical landscape. Four main issues were proposed: (i) spermatogenesis and radiobiological general concepts; (ii) impairment of spermatogenesis; (iii) impairment of testosterone-producing Leydig cells; (iv) clinical radiotherapy evidence in oncology.
CONCLUSION
This review can be useful in daily clinical work and offer some directions for future research.
背景
精子发生是一个动态的细胞分化过程。电离辐射会损害精子发生，精原细胞比精母细胞或精细胞更敏感。基于这一假设，并且由于肿瘤治愈率的提高，如今，生育力保存代表了公共卫生的需求。
目的
讨论放射治疗对男性生育力的风险，并提高日常临床实践中对男性生育力的肿瘤学认识。
材料和方法
在 PubMed 和 Clinicaltrials.gov 数据库中搜索英文文献。
结果
我们提供了临床概况的概述。提出了四个主要问题：（i）精子发生和放射生物学的一般概念；（ii）精子发生的损害；（iii）产生睾酮的睾丸间质细胞的损害；（iv）肿瘤学中的临床放射治疗证据。
结论
本综述可用于日常临床工作，并为未来的研究提供一些方向。
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