Foratori-Junior Gerson Aparecido, Ventura Talita Mendes Oliveira, Grizzo Larissa Tercilia, Carpenter Guy Howard, Buzalaf Marília Afonso Rabelo, Sales-Peres Silvia Helena de Carvalho
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil.
Centre for Host-Microbiome Interactions, Faculty of Dental, Oral & Craniofacial Sciences, Guy's Campus, King's College London, London SE1 1UL, UK.
Metabolites. 2022 Nov 10;12(11):1091. doi: 10.3390/metabo12111091.
Obesity and pregnancy may have synergistic effects on periodontal condition, and proteomics could be an ideal approach to highlight the pathophysiological mechanisms associated with these outcomes. This study analyzed the salivary proteomics related to obesity and periodontitis in women during pregnancy (T1) and after delivery (T2). Initially, 126 women were recruited and forty were allocated into groups: with obesity and periodontitis (OP); with obesity, but without periodontitis (OWP); with normal BMI, but with periodontitis (NP); with normal BMI and without periodontitis (NWP). Whole-mouth saliva was collected in T1 and T2, and proteins were extracted and individually processed by label-free proteomics (). The up-regulations of , , and were related to both obesity and periodontitis, separately. and were up-regulated in periodontitis cases, while (mainly , , ) and were down-regulated. The high abundances of , , , and , , , and were significant in the combination of obesity and periodontitis. Obesity and periodontitis remarkably altered the proteome of the saliva during pregnancy with substantial alterations after delivery.
肥胖与妊娠可能对牙周状况产生协同作用，而蛋白质组学可能是揭示与这些结果相关的病理生理机制的理想方法。本研究分析了孕期（T1）和产后（T2）女性中与肥胖和牙周炎相关的唾液蛋白质组学。最初，招募了126名女性并将40名分为以下几组：肥胖且患有牙周炎（OP）；肥胖但未患牙周炎（OWP）；体重指数正常但患有牙周炎（NP）；体重指数正常且未患牙周炎（NWP）。在T1和T2时收集全口唾液，提取蛋白质并通过无标记蛋白质组学单独处理。 、 和 的上调分别与肥胖和牙周炎相关。 和 在牙周炎病例中上调，而 （主要是 、 ）和 下调。 、 、 、 以及 、 、 的高丰度在肥胖与牙周炎的组合中具有显著性。肥胖和牙周炎在孕期显著改变了唾液蛋白质组，产后有实质性变化。
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